96
Participants
Start Date
December 31, 2013
Primary Completion Date
April 30, 2015
Study Completion Date
April 30, 2015
Dapivirine Vaginal Ring
Dapivirine, a non-nucleoside reverse-transcriptase inhibitor (NNRTI), is a substituted amino- pyrimidine (DAPY) derivative with potent antiviral activity against HIV-1. Dapivirine is chemically described as 4-\[\[4-\[(2,4,6-trimethylphenyl)amino\]-2- pyrimidinyl\]amino\]benzonitrile.6 The dapivirine matrix VR is a flexible ring containing 25 mg of drug substance dispersed in a platinum-catalyzed-cured silicone matrix. Dapivirine is known to be well-suited for delivery via VR
Placebo Vaginal Ring
The placebo VR is a flexible, platinum-catalyzed-cured silicone matrix ring, identical to dapivirine Ring-004, containing no active drug.
Magee Women's Hospital of UPMC, Pittsburgh
Case CRS, Case Western Reserve University, 2061 Cornell Road, Room 303, Cleveland
Alabama CRS, 84519th Street South, BBRB 203A, Birmingham
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
International Partnership for Microbicides, Inc.
INDUSTRY