SARC023: Ganetespib and Sirolimus in Patients With MPNST (Malignant Peripheral Nerve Sheath Tumors)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

December 31, 2013

Primary Completion Date

April 30, 2018

Study Completion Date

July 31, 2018

Conditions
Malignant Peripheral Nerve Sheath Tumors (MPNST)Sarcoma
Interventions
DRUG

ganetespib

Phase 1 Dose 1: 150 mg/m² IV on days 1, 8, and 15 intravenously over 1 hour; Phase 1 Dose 2: 200 mg/m² IV on days 1, 8, and 15 intravenously over 1 hour; Phase 2: 200 mg/m² IV on days 1, 8, and 15 intravenously over 1 hour

DRUG

Sirolimus

4mg taken orally once daily on a continuous dosing schedule; Loading dose 12 mg on cycle 1 day 1 only.

Trial Locations (7)

20010

Children's National Medical Center, Washington D.C.

20892

National Cancer Institute, Bethesda

48109

University of Michigan, Ann Arbor

52242

University of Iowa, Iowa City

63130

Washington University, St Louis

84112

Huntsman Cancer Institute, Salt Lake City

90403

Sarcoma Oncology Center, Santa Monica

All Listed Sponsors
collaborator

Synta Pharmaceuticals Corp.

INDUSTRY

collaborator

United States Department of Defense

FED

lead

Sarcoma Alliance for Research through Collaboration

OTHER

NCT02008877 - SARC023: Ganetespib and Sirolimus in Patients With MPNST (Malignant Peripheral Nerve Sheath Tumors) | Biotech Hunter | Biotech Hunter