Carbohydrate Antigen 125-guided Therapy in Heart Failure

Up titration of loop diuretics according to plasma levels of CA125 in the active arm

Consider statins in all patients in the active arm

Consider omega-3 polyunsaturated fatty acids in the active arm

Frequency of monitoring according plasma evolution of CA125 in the active arm.

All patients should be treated following standard european guidelines regarding angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, aldosterone antagonists, diuretics, ivabradine and other treatments such as (diet, anticoagulants, antiarrhythmics, statins, omega-3 polyunsaturated fatty acids, digoxin, nitrates and vasoactive group).

All patients should be treated following standard european guidelines regarding angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, ivabradine and other treatments such as (diet, anticoagulants, antiarrhythmics, digoxin, nitrates and vasoactive group).