A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

February 26, 2014

Primary Completion Date

February 22, 2017

Study Completion Date

September 5, 2019

Conditions
Advanced Solid Tumors
Interventions
DRUG

axitinib

Axitinib: tablets, dosage range 2 - 5 mg, given orally twice daily on a continuous dosing schedule in 28 days cycles.

DRUG

crizotinib

Crizotinib: capsules, dosage range 200-250 mg, given orally twice daily or every day on a continuous dosing schedule in 28 days cycle.

DRUG

axitinib

Axitinib: tablets, dosage be defined based on Arm 1 results, given orally twice daily on a continuous dosing schedule in 28 days cycles.

DRUG

crizotinib

Crizotinib: capsules, dosage be defined based on Arm 1 results, given orally twice daily or every day on a continuous dosing schedule in 28 days cycle.

DRUG

axitinib

Axitinib: tablets, dosage be defined based on Arm 1 results, given orally twice daily on a continuous dosing schedule in 28 days cycles.

DRUG

crizotinib

Crizotinib: capsules, dosage be defined based on Arm 1 results, given orally twice daily or every day on a continuous dosing schedule in 28 days cycle.

Trial Locations (17)

44106

Cleveland Clinic Taussig Cancer Center Investigational Pharmacy, Cleveland

46202

Investigational Drug Services IUHSCC, Indianapolis

IU Health University Hospital, Indianapolis

48201

Wayne State University, Dept. of Oncology, Detroit

53705

University Station Ophthalmology Clinic, Madison

53792

University of Wisconsin Hospital and Clinics, Madison

55455

University of Minnesota Health Clinics and Surgery Center, Minneapolis

University of Minnesota Medical Center, Fairview IDS Pharmacy, Minneapolis

University of Minnesota Medical Center, Fairview, Minneapolis

University of Minnesota Physicians Masonic Cancer Center, Minneapolis

60637

University of Chicago Medical Center, Chicago

84112

Huntsman Cancer Hospital, Salt Lake City

Huntsman Cancer Institute, Salt Lake City

84132

John A Moran Eye Center, Salt Lake City

02114

Massachusetts General Hospital, Boston

EC1A 7BE

St Bartholomew's Hospital - Barts Health NHS Trust, London

SW3 6JJ

The Royal Marsden NHS Foundation Trust, Royal Marsden Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT01999972 - A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter