Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

April 30, 2013

Primary Completion Date

May 31, 2016

Study Completion Date

May 31, 2016

Conditions
Astrocytoma, Oligoastrocytoma, MixedGanglioneuromaGliomaGangliogliomaGlioblastoma Multiforme Glioma
Interventions
DRUG

Irinotecan

"Irinotecan IV over 90 minutes on Days 1, 15, and 29 of each cycle (except Cycle 1, when it will be started on Day 29)~Note: Irinotecan can be removed from the treatment plan at the discretion of the healthcare provider."

DRUG

Bevacizumab

Bevacizumab will be given intravenously AFTER the irinotecan infusion is complete on Days 1, 15, and 29 of each cycle. The first dose will be given over 90 minutes, but doses after that may be given over 30-60 minutes.

DEVICE

FDOPA-PET/MRI imaging

FDOPA-PET/MRI imaging Baseline (before beginning Cycle 1 treatment) Cycle 1, Day 29 (before receiving your treatment with bevacizumab) and end of treatment or time of relapse

Trial Locations (1)

63110

Washington University School of Medicine, St Louis

All Listed Sponsors
lead

Washington University School of Medicine

OTHER

NCT01999270 - Evaluation of FDOPA-PET/MRI in Pediatric Patients With CNS Tumors | Biotech Hunter | Biotech Hunter