1,326
Participants
Start Date
December 16, 2013
Primary Completion Date
April 18, 2017
Study Completion Date
April 18, 2017
Ertugliflozin 5 mg
Ertugliflozin, 5 mg, oral, once daily, from Day 1 to Week 104
Ertugliflozin 10 mg
Ertugliflozin, 10 mg, oral, once daily from Day 1 to Week 104.
Glimerpiride
Glimepiride, oral tablets, initiated at 1 mg daily and titrated up to the maximum approved dose (8 mg daily based on the local country label) or maximum tolerated dose
Placebo to Ertugliflozin
Matching placebo to ertugliflozin, 5 mg and/or 10 mg, oral, once daily, from Day 1 to Week 104
Placebo to Glimepiride
Matching placebo to glimepiride, 1 mg or 2 mg, oral, once daily, from Day 1 to Week 104.
Metformin
Participants are to remain on their stable doses of metformin (oral, \>=1500 mg/day) while receiving blinded investigational product during the double-blind treatment period. Participants on metformin \<1500 at screening are up-titrated to \>= 1500 daily.
Sitagliptin
Open label, oral, once daily, rescue medication as required.
Collaborators (1)
Pfizer
INDUSTRY
Merck Sharp & Dohme LLC
INDUSTRY