A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma

PHASE1CompletedINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

February 18, 2014

Primary Completion Date

January 31, 2019

Study Completion Date

January 11, 2024

Conditions
Multiple Myeloma
Interventions
DRUG

Daratumumab

Administered by either intravenous or subcutaneous infusions, in combination with the applicable backbone treatment.

DRUG

Velcade

Administered subcutaneously in accordance with product labeling and local standards.

DRUG

Pomalidomide

Administered orally in accordance with product labeling and local standards.

DRUG

Dexamethasone

Administered intravenously or orally in accordance with product labeling and local standards.

DRUG

Melphalan

Administered orally in accordance with product labeling and local standards.

DRUG

Prednisone

Administered intravenously or orally in accordance with product labeling and local standards.

DRUG

Thalidomide

Administered orally in accordance with product labeling and local standards.

DRUG

Diphenhydramine

Administered in prophylactic doses intravenously (or equivalent) in accordance with product labeling and local standards.

DRUG

Acetaminophen

Administered in prophylactic doses by mouth in accordance with product labeling and local standards.

DRUG

Carfilzomib

Administered intravenously in accordance with product labeling and local standards.

DRUG

Lenalidomide

Administered orally in accordance with product labeling and local standards.

DRUG

Montelukast

Administered intravenously or orally only with the first daratumumab dose in accordance with product labeling and local standards.

Trial Locations (22)

Unknown

Duarte

Atlanta

Chicago

Indianapolis

Boston

New York

Rochester

Charlotte

Philadelphia

Dallas

Lille

Nantes

Paris

Pessac

Toulouse

Tours

Badalona

Barcelona

Madrid

Pamplona

Salamanca

Valencia

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT01998971 - A Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Treatments for the Treatment of Patients With Multiple Myeloma | Biotech Hunter | Biotech Hunter