A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

April 30, 2014

Primary Completion Date

April 30, 2019

Study Completion Date

April 30, 2019

Conditions
Corneal NeovascularizationCorneal Graft Failure
Interventions
DRUG

Avastin® (bevacizumab)

One time subconjunctival injection of 0.1 mL (2.5 mg) bevacizumab followed by topical treatment with 1% solution bevacizumab four times a day for four weeks.

DRUG

0.9% NaCl & Refresh Liquigel

One-time subconjunctival injection of 0.1mL 0.9% NaCl followed by topical treatment with Refresh Liquigel four times a day for four weeks.

Trial Locations (3)

10065

New York Presbyterian Hospital, New York

33136

Bascom Palmer Eye Institute, Miami

02114

Massachusetts Eye and Ear Infirmary, Boston

All Listed Sponsors
collaborator

United States Department of Defense

FED

collaborator

Bascom Palmer Eye Institute

OTHER

collaborator

New York Presbyterian Hospital

OTHER

lead

Reza Dana, MD

OTHER

NCT01996826 - A Multi-Center Study of the Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival | Biotech Hunter | Biotech Hunter