32
Participants
Start Date
December 31, 2013
Primary Completion Date
September 27, 2023
Study Completion Date
September 27, 2023
low dose 5'-azacitidine
5'-azacitadine will be given at a low dose of 32mg/m2 S.C for 5 days every 28 days (a cycle). Dose de-escalation will be permitted for hematologic and non- hematologic toxicities. Patients will start taking the study drug between days 60-120 post TCD allogeneic hematopoietic stem cell transplant and up to a year post-transplant or until there is a toxicity that requires cessation of therapy. Therefore patients will get between 8-10 cycles. Patients who come off-study for reasons unrelated to toxicities before completing 4 cycles will be replaced Since most cases of relapse occur early post transplant, in the first year, this is the most appropriate time to intervene. Treatment will start as soon as possible.
Memorial Sloan Kettering Cancer Center, New York
Memorial Sloan Kettering Westchester (Consent and Follow-up), Harrison
Memorial Sloan Kettering Commack (Consent and Follow-up), Commack
Memorial Sloan Kettering at Basking Ridge (Consent and Follow-up), Basking Ridge
Memorial Sloan Kettering Monmouth (Consent and Follow-up), Middletown
Memorial Sloan Kettering Bergen (Consent and Follow-up), Montvale
Memorial Sloan Kettering Nassau (Consent and Follow-up), Rockville Centre
Memorial Sloan Kettering Cancer Center
OTHER