41
Participants
Start Date
December 16, 2013
Primary Completion Date
November 9, 2016
Study Completion Date
November 9, 2016
Bevacizumab
Bevacizumab 15 milligrams per kilogram (mg/kg) administered via IV infusion on Day 1 of each 21-day cycle until disease progression or death, whichever occurs first.
Carboplatin
Carboplatin fixed dose of AUC=6 mg/mL\*min administered by IV infusion on Day 1 of each 21-day dose escalation and expansion cycles. Carboplatin will be administered for a maximum of 6 cycles or until disease progression or unacceptable toxicity, whichever is first.
DNIB0600A
DNIB0600A at an initial dose of 1.2 mg/kg will be administered via IV infusion further following a dose-escalation until DLT under consultation of the investigator on Day 1 of 21 day dose-escalation cycle. RP2D will be administered further in dose-expansion for until disease progression or death, whichever occurs first.
The Sarah Cannon Research Inst, Nashville
The University of Oklahoma, Oklahoma City
Massachusetts General Hospital., Boston
Dana Farber Cancer Inst., Boston
Lead Sponsor
Genentech, Inc.
INDUSTRY