NCT01992341 - AMG 386 Drug-Drug Interaction Study With Paclitaxel | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

July 31, 2012

Primary Completion Date

August 31, 2013

Study Completion Date

September 30, 2014

Conditions

Advanced Solid Tumors

Interventions

DRUG

AMG 386

Weekly 15 mg/kg of AMG 386 in combination with three weeks on/ one week off 80mg/m2 of paclitaxel. Continued therapy with AMG 386 with or without paclitaxel until progression, unacceptable toxicity develops, or study withdrawal.

DRUG

Paclitaxel

Three weeks on/ one week off 80mg/m2 of paclitaxel in combination with weekly 15 mg/kg of AMG 386 . Continued therapy with AMG 386 until progression, unacceptable toxicity develops, or study withdrawal. A cycle consists of 3 weeks on / 1 week off of paclitaxel.

Trial Locations (2)

80045

University of Colorado Cancer Center, Aurora

84112

University of Utah Huntsman Cancer Institute, Salt Lake City