Prehospital Tranexamic Acid Use for Traumatic Brain Injury

PHASE2CompletedINTERVENTIONAL
Enrollment

967

Participants

Timeline

Start Date

May 31, 2015

Primary Completion Date

November 7, 2017

Study Completion Date

November 7, 2017

Conditions
Traumatic Brain Injury
Interventions
DRUG

1 gram Tranexamic Acid (TXA)

TXA produces an antifibrinolytic effect by competitively inhibiting the activation of plasminogen to plasmin.

DRUG

2 grams TXA

TXA produces an antifibrinolytic effect by competitively inhibiting the activation of plasminogen to plasmin.

DRUG

0.9% Sodium Chloride injectable

Loading dose of 0.9% Sodium Chloride solution given prior to hospital arrival followed by a placebo of 0.9% Sodium Chloride solution infusion over 8 hours after hospital arrival. No active drug is added to the solution.

Trial Locations (12)

35249

Alabama Resuscitation Center, Birmingham

45267

University of Cincinnati Medical Center, Cincinnati

53226

Milwaukee Resuscitation Research Center, Milwaukee

55101

St Paul Regions Hospital, Saint Paul

55415

Hennepin County Medical Center, Minneapolis

55905

Mayo Clinic Rochester, Rochester

75390

Dallas Center for Resuscitation Research, Dallas

77030

Memorial Hermann Hospital - Texas Medical Center, Houston

98104

Harborview Medical Center, Seattle

97239-3098

Oregon Health & Sciences University, Portland

V5Z 1 M9

British Columbia Regional Coordinating Center, Vancouver

M5B 1W8

Toronto RescuNet, Toronto

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

U.S. Army Medical Research and Development Command

FED

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

collaborator

Heart and Stroke Foundation of Canada

OTHER

collaborator

American Heart Association

OTHER

collaborator

Defence Research and Development Canada

INDUSTRY

lead

University of Washington

OTHER