A Study of Lebrikizumab (RO5490255) in Participants With Severe Oral Corticosteroids (OCS) Dependent Asthma

PHASE2CompletedINTERVENTIONAL
Enrollment

230

Participants

Timeline

Start Date

February 28, 2014

Primary Completion Date

December 20, 2016

Study Completion Date

December 20, 2016

Conditions
Asthma
Interventions
DRUG

Lebrikizumab

Lebrikizumab will be administered as SC injections every 4 weeks at dose and schedule described in arm description.

DRUG

Placebo

Placebo matching to lebrikizumab will be administered as SC injections every 4 weeks as per schedule described in arm description.

Trial Locations (71)

1051

NZ Respiratory & Sleep Institute, Auckland

1070

Clin Univ de Bxl Hôpital Erasme, Brussels

2900

Gentofte Hospital, Klinik for Allergi, Hellerup

3143

Clinical Trials Unit, Bay of Plenty District Health Board, Tauranga

3168

Monash Medical Centre; Respiratory and Sleep Medicine, Clayton

3600

Longartsenpraktijk, Genk

4102

Princess Alexandra Hospital, Department of Respiratory and Sleep Medicine, Brisbane

4204

University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik

6009

Institute for Respiratory Health Inc, Nedlands

9000

UZ Gent, Ghent

10029

Mount Sinai Medical Center, New York

15706

Complejo Hospitalario Universitario de Santiago; Servicio de Neumología, Santiago de Compostela

31707

Georgia Pollens, Albany

33135

South Florida Research Center, Inc., Miami

33604

CHU de Haut Leveque, Pessac

34295

Hôpital Arnaud de Villeneuve, Montpellier

37007

Hospital Clinico Universitario de Salamanca; Servicio de Neumologia, Salamanca

38043

CHU de Grenoble - Hôpital André Michallon, Grenoble

44093

CHU Nantes - Hôpital Laennec; Service de Pneumologie, Nantes

44100

Instituto Jalisciense de Investigacion Clinica S.A. de C.V., Guadalajara

44130

Centro Investigacion Medico Biologica y Terapia Avanzada, Guadalajara

46017

Hospital Universitario Doctor Peset, Valencia

67091

Nouvel Hôpital Civil; Pôle de Pathologie Thoracique, Strabourg

69004

Hôpital de La Croix Rousse, Lyon

74136

Allergy & Immunology, Tulsa

75069

Metroplex Pulmonology & Sleep Center, McKinney

75877

Hopital Bichat Claude Bernard ; Service de Pneumologie, Paris

76800

Centro Integral Médico SJR SC, Querétaro

77008

Pioneer Research Solutions, Houston

90808

Allergy & Asthma Care Center of Southern California, Long Beach

93301

Kern Allergy Med Clinic, Inc., Bakersfield

94275

CH de Bicetre; Pneumologie, Le Kremlin-Bicêtre

98405

Pulmonary Consultants PLLC, Tacoma

M5T 3A9

Inspiration Research Limited, Toronto

618 00

Hornmed, Brno

460 63

Nemocnice Liberec; KNL a.s. - TRN, Liberec

741-01

Nemocnice Nový Jičín, Nový Jičín

337 22

Rokycanska nemocnice, Rokycany

06001

CHU de Nice, Nice

1105 AZ

Academisch Medisch Centrum; Afdeling Longziekten, F5-258, Amsterdam

2134 TM

Spaarne Ziekenhuis Hoofddorp; Long Geneeskunde, Hoofddorp

3435 CM

Antonius Ziekenhuis; Dept of Lung Diseases, Nieuwegein

Unknown

Dunedin Hospital, Dunedin

Medical Research Inst. of New Zealand; Respiratory, Wellington

31-024

Specjalistyczny Osrodek Alergologiczno-Internistyczny ALL-MED, Krakow

31-624

Malopolskie Centrum Alergologii, Krakow

90-153

SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi, Lodz

63-400

Specjalistyczna Poradnia Pulmonologiczna, Ostrów Wielkopolski

41-707

Niepubliczny Zaklad Opieki Zdrowotnej PROFILAKTYKA Wladyslaw Pierzchala, Ruda Śląska

02-507

Klinika Chorób Wewnetrznych i Alergologii MSW, Warsaw

50-220

EMC Instytut Medyczny SA; Przychodnia przy ulicy Łowieckiej, Wroclaw

00725

San Juan Bautista School of Medicine-Clinical Research Unit, Caguas

00739

Advanced Medical Concepts, PSC, Cidra

934 01

ZAPA JJ Sro, Levice

052 01

Plucna ambulancia, Spišská Nová Ves

08025

Hospital de la Santa Creu; i Sant Pau, Barcelona

08036

Hospital Clinic de Barcelona, Barcelona

BT9 7AB

Belfast City Hospital; Respiratory Department, Belfast

B9 5SS

Heartlands Hospital; Respiratory Department, Birmingham

G12 0YN

Gartnavel General Hospital; Respiratory Department, Glasgow

G31 2ER

New Lister Buliding, Level 1; Clinical Research Facility, Glasgow

G51 4TF

Royal Hospital For Children, Glasgow

SO16 6YD

Southampton General Hospital; Respiratory Department, Hampshire

LE1 5WW

Leicester Royal Infirmary NHS Trust, Leicester

LE3 9QP

Glenfield Hospital; Respiratory -Allergy Unit, Leicester

EC1A 7BE

St Bartholomew's Hospital (Barts); Respiratory Department, London

SW3 6NP

Royal Brompton Hospital; Respiratory Department, London

M23 9LT

Wythenshawe Hospital; North West Lung Research Centre, Manchester

NE7 7DN

Freeman Hospital; Respiratory Department, Newcastle upon Tyne

PL6 8DH

Derriford Hospital; The Lind Research Department, Plymouth

S10 2JF

Sheffield Clinical Research Facility; National Institute for Health Research, Sheffield

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01987492 - A Study of Lebrikizumab (RO5490255) in Participants With Severe Oral Corticosteroids (OCS) Dependent Asthma | Biotech Hunter | Biotech Hunter