Aza-SAHA-GBM With AutoSCT for Refractory Lymphoma

Starting dose 15 mg/ m2 by vein on Day -11.

1000 mg by vein on Day -11 through Day -2.

Loading dose 75 mg/m2 by vein followed by 22775 mg/m2 by vein on Day -8.

Busulfan test dose 32 mg/m2 by vein either as outpatient before Day -12 or as inpatient on Day -11. Busulfan pharmacokinetics performed with test dose and first dose on Day -8. Doses on Days -6 and -5 adjusted to target an AUC of 4,000 microMol.min-1.

60 mg/m2 by vein on Days -3 and -2.

8 mg by vein twice a day from Day -11 AM to Day -2 PM.

Caphosol oral rinses 30 mL four times a day used from Day -9.

Oral glutamine, 15 g four times a day, swished, gargled and swallowed from Day -9.

100 mg by vein or mouth three times a day from Day -1.

375 mg/m2 by vein on Days -9.