Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water

PHASE1CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

January 31, 2013

Primary Completion Date

March 31, 2013

Study Completion Date

December 31, 2013

Conditions
Dental CariesDental Fluorosis
Interventions
OTHER

Meal prepared with non fluoridated water

Ingestion of a typical brazilian meal (rice, beans, meat, french beans, carrots, gelatin and juice) prepared with purified water containing a fluoride dose of 0.8 ug of fluoride/kg body weight (resulting of the natural fluoride concentration in foods).

OTHER

Meal prepared with fluoridated water

Ingestion of a typical brazilian meal (rice, beans, meat, french beans, carrots, gelatin and juice) prepared with fluoridated water (1 ug of fluoride/mL), to provide a total intake of approximately 12 ug of fluoride/kg body weight.

OTHER

Non fluoridated water

Ingestion of purified water with addition of fluoride to provide a total intake of approximately 0.8 ug of fluoride/kg body weight, which represented the same fluoride ingestion dose of the experimental phase with meal prepared with non fluoridated water.

OTHER

Fluoridated water

Ingestion of fluoridated water (1 ug F/mL), to provide a total intake of approximately 12 ug of fluoride/kg body weight.

OTHER

Meal prepared to provide a fluoride dose of 60 ug F/kg

Ingestion of a typical Brazilian meal (rice, beans, meat, french beans, carrots, gelatin and juice) prepared with non-fluoridated water, with sodium fluoride solution added to the juice to provide a total intake of approximately 60 ug of fluoride/kg body weight.

OTHER

Meal prepared to provide a fluoride dose of 120 ug F/kg

Ingestion of a typical Brazilian meal (rice, beans, meat, french beans, carrots, gelatin and juice) prepared with non-fluoridated water, with sodium fluoride solution added to the juice to provide a total intake of approximately 60 ug of fluoride/kg body weight.

Trial Locations (1)

13414903

Piracicaba Dental School, University of Campinas, Piracicaba

All Listed Sponsors
lead

University of Campinas, Brazil

OTHER

NCT01978041 - Fluoride Bioavailability After Ingestion of Water or Foods Prepared With Fluoridated Water | Biotech Hunter | Biotech Hunter