Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor (Rogaratinib)

PHASE1CompletedINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

December 30, 2013

Primary Completion Date

March 11, 2019

Study Completion Date

January 9, 2020

Conditions
Neoplasms
Interventions
DRUG

Rogaratinib (BAY1163877) oral solution

Participants received Rogaratinib oral solution as a single dose on Cycle 1 Day 1 (C1D1) and twice daily (BID) from Cycle 1 Day 3 (C1D3) onward for the remaining 19 days of Cycle 1. For subsequent cycles, study drug was administered twice daily for 21 days each Cycle.

DRUG

Rogaratinib (BAY1163877) oral tablet

Participants received Rogaratinib oral tablet as a single dose on C1D1 and BID from C1D3 onward for the remaining 19 days of Cycle 1. For subsequent cycles, study drug was administered twice daily for 21 days each Cycle.

DRUG

Rogaratinib (BAY1163877) 800 mg BID

Participants received Rogaratinib 800 mg oral tablet as a single dose on C1D1 and BID (in total 1600 mg) from C1D3 onward for the remaining 19 days of Cycle 1. For subsequent cycles, study drug was administered twice daily for 21 days each Cycle.

Trial Locations (29)

1205

Geneva

7000

Chur

9007

Sankt Gallen

15232

Pittsburgh

20246

Hamburg

21079

Dijon

25030

Besançon

28034

Madrid

28041

Madrid

39120

Magdeburg

45147

Essen

46014

Valencia

50937

Cologne

59020

Lille

69008

Lyon

69120

Heidelberg

72076

Tübingen

92637

Weiden

94010

Créteil

97080

Würzburg

119228

Singapore

169610

Singapore

60611-2908

Chicago

Unknown

Chicago

01307

Dresden

03080

Seoul

03722

Seoul

135-710

Seoul

08035

Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY

NCT01976741 - Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor (Rogaratinib) | Biotech Hunter | Biotech Hunter