Midazolam Whole Body Physiologically Based Pharmacokinetic Model

CompletedOBSERVATIONAL
Enrollment

20

Participants

Timeline

Start Date

January 31, 2013

Primary Completion Date

May 31, 2014

Study Completion Date

May 31, 2014

Conditions
Respiratory FailureComa
Interventions
PROCEDURE

Blood and urine sampling

"Blood and urine sampling will follow this schedule:~* 24h: blood (3ml)~* 48h: blood (3ml) and urine~* End of infusion: blood (3ml)~* 6h after end of infusion: blood (3ml) and urine. Blood samples will be centrifuged for 10 minutes at 3300rpm, then supernatant will be placed into test tubes and stored at -20°C; urine samples will be freeze at -20°C as well.~Then all frozen samples will be analyzed to get Midazolam concentrations."

Trial Locations (1)

21100

Azienda Ospedaliera Ospedale di Circolo e Fondazione Macchi, Varese

All Listed Sponsors
collaborator

University of Milan

OTHER

lead

Università degli Studi dell'Insubria

OTHER

NCT01973894 - Midazolam Whole Body Physiologically Based Pharmacokinetic Model | Biotech Hunter | Biotech Hunter