A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

364

Participants

Timeline

Start Date

January 8, 2014

Primary Completion Date

March 15, 2017

Study Completion Date

May 24, 2023

Conditions
ALK-positive Non Small Cell Lung Cancer (NSCLC) and ROS1-positive NSCLC
Interventions
DRUG

PF-06463922

Oral, starting dose 10mg once a day, dose escalation in Phase 1 until recommended Phase 2 dose determined, continuous daily dosing, cycles lasting 21 days

DRUG

Crizotinib

Oral, starting dose of 250 mg BID continuous daily dosing every 21 days

Trial Locations (77)

100

National Taiwan University Hospital, Taipei

1011

Hospital of Lausanne (CHUV), Lausanne

2050

Chris O'Brien Lifehouse, Sydney

Royal Prince Alfred Hospital, Sydney

Chris O'Brien Lifehouse, Sydney Local Health District [rpa]

2650

University Hospital Antwerp, Edegem

3000

Peter MacCallum Cancer Centre, Melbourne

3050

Royal Melbourne Hospital, Parkville

8401

Kantonsspital Winterthur, Winterthur

10002

National Taiwan University Hospital, Taipei

10022

Rockefeller Patient Pavilion - Memorial Sloan Kettering, New York

10065

Memorial Sloan Kettering Cancer Center, New York

13210

SUNY Upstate Medical University, Syracuse

14621

Rochester Regional Health System, Rochester

19111

Fox Chase Cancer Center, Philadelphia

20007

Georgetown University Medical Center, Washington D.C.

20132

Dipartimento di Oncologia Medica, UO Medicina 1Q A, Unita' Nuovi Farmaci e Terapie Innovative, Milan

20141

Unita di Farmacologia Clinica e Nuovi Farmaci, Milan

28223

Hospital Universitario Quiron Madrid, Pozuelo de Alarcón

31008

Clinica Universidad De Navarra, Pamplona

31059

Institut Universitaire du Cancer de Toulouse (IUCT-O), Toulouse

33081

Struttura Operativa Complessa Oncologia, Aviano (PN)

35033

CHU de Rennes - Hôpital Pontchaillou - CIC Inserm, Rennes

CHU de Rennes - Hôpital Pontchaillou, Rennes

37203

Sarah Cannon Research Institute (Pharmacy), Nashville

Tennessee Oncology PLLC, Nashville

38043

CHU Grenoble/ Hôpital Albert Michallon, Grenoble

43205

The Ohio State University, Columbus

43210

The Ohio State University, Columbus

43221

The Ohio State University, Columbus

48201

Karmanos Cancer Institute, Detroit

Karmanos Center Institute, Detroit

48334

Karmanos Cancer Institute, Farmington Hills

50937

Universitaetsklinik Koeln, Cologne

63110

Barnes-Jewish Hospital, St Louis

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center-West County, Creve Coeur

72703

Highlands Oncology Group/Research, Fayetteville

72758

Highlands Oncology Group, Rogers

80045

University of Colorado Cancer Center, Aurora

University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP), Aurora

University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP), Aurora

University of Colorado Hospital - Anschutz Outpatient Pavillion (AOP), Aurora

University of Colorado Hospital, Aurora

94805

Institut Gustave Roussy (comite poumon-pneumologie), Villejuif

Institut Gustave Roussy- Pharmacie-Unite Essais Cliniques, Villejuif

119074

National University Hospital, Singapore

119082

National University Hospital Medical Centre, Singapore

168583

National Cancer Center, Singapore

169610

National Cancer Center, Singapore

92868-3201

Chao Family Comprehensive Cancer Center, Orange

UC Irvine Medical Center, Orange

06504

MDZ: Yale-New Haven Hospital, New Haven

06510

Smilow Cancer Hospital at Yale-New Haven, New Haven

02114

Massachusetts General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

V5Z 4E6

British Columbia Cancer Agency-Vancouver Centre, Vancouver

K1H 8L6

The Ottawa Hospital Cancer Centre, Ottawa

M5G 2M9

Princess Margaret Cancer Centre, Toronto

Unknown

Department of Clinical Oncology, Prince of Wales Hospital, Shatin

06132

Oncologia Medica, Perugia

464-8681

Aichi Cancer Center Hospital, Nagoya

466-8560

Nagoya University Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

060-8648

Hokkaido University Hospital, Sapporo

673-8558

Hyogo Cancer Center, Akashi

589-8511

Kindai University Hospital, Sayama

411-8777

Shizuoka Cancer Center, Sunto-gun

104-0045

National Cancer Center Hospital, Chuo-ku

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

135-8550

The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo

03080

Seoul National University Hospital / Department of Internal Medicine, Seoul

08028

Hospital Universitario Quiron Dexeus, Barcelona

08035

Hospital Universitari de la Vall D'Hebron Edificio General. Planta Baja. UITM. Servicio de Oncologia, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT01970865 - A Study Of PF-06463922 An ALK/ROS1 Inhibitor In Patients With Advanced Non Small Cell Lung Cancer With Specific Molecular Alterations | Biotech Hunter | Biotech Hunter