A Phase I Study Of Panobinostat/Lenalidomide/Bortezomib/Dex for Relapsed And Relapsed/Refractory Multiple Myeloma

PHASE1CompletedINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

October 31, 2013

Primary Completion Date

March 31, 2019

Study Completion Date

September 30, 2021

Conditions
Multiple Myeloma in Relapse
Interventions
DRUG

Panobinostat

\- Panobinostat - single oral dose on days 1, 3, 5, 8, 10 and 12 and followed by a 9-day rest period.

DRUG

Dexamethasone

Dexamethasone - oral dose on Days 1, 2, 4, 5, 8, 9, 11 and 12 followed by a 9-day rest period

DRUG

Lenalidomide

Lenalidomide - daily oral dose on Days 1-14 followed by 7-day rest period

DRUG

Bortezomib

Bortezomib - subcutaneous injection, on Days 1, 4, 8, and 11 followed by a 10-day rest period. At least 72 hours should elapse between bortezomib doses, but if needed an interval of 70 hours is permitted

Trial Locations (4)

27710

Duke University Medical Center, Durham

02115

Brigham and Women's Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

Dana-Farber Cancer Institute

OTHER

NCT01965353 - A Phase I Study Of Panobinostat/Lenalidomide/Bortezomib/Dex for Relapsed And Relapsed/Refractory Multiple Myeloma | Biotech Hunter | Biotech Hunter