N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

October 31, 2013

Primary Completion Date

June 30, 2015

Study Completion Date

October 31, 2015

Conditions
HIVEndothelial DysfunctionOxidative Stress
Interventions
DIETARY_SUPPLEMENT

PharmaNAC (N-acetylcysteine)

"PharmaNAC is considered a nutritional supplement and can be obtained without a prescription. All participants will be asked to ingest two tablets twice per day during this trial. For those randomized to PharmaNAC 1800 mg twice daily, this will be two active tablets twice per day. For those randomized to PharmaNAC 900 mg twice daily, this will be one active tablet twice per day and one matching placebo tablet twice per day. For those randomized to placebo, this will be two matching placebo tablets twice per day.~PharmaNAC can be taken with or without food. The effervescent tablets should be dissolved in 8 oz. of water or juice prior to oral intake. Each participant will take study drug and/or matching placebo for 8 weeks (up to 60 days)."

DIETARY_SUPPLEMENT

Matching placebo

Inactive pill that matches PharmaNAC on taste, color, and appearance.

Trial Locations (1)

46202

Indiana University Health University Hospital, Indiana Clinical Research Center, Indianapolis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

BioAdvantex Pharma

UNKNOWN

lead

Indiana University

OTHER