Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure With Reduced Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-REDUCED)

PHASE2CompletedINTERVENTIONAL
Enrollment

456

Participants

Timeline

Start Date

November 29, 2013

Primary Completion Date

May 14, 2015

Study Completion Date

June 9, 2015

Conditions
Heart Failure
Interventions
DRUG

Vericiguat (BAY1021189) (1.25 mg)

1.25 mg BAY1021189 tablets

DRUG

Vericiguat (BAY1021189) (5 mg)

5 mg BAY1021189 tablets

DRUG

Placebo

Trial Locations (157)

220

New Taipei City

813

Kaohsiung City

1032

Budapest

1200

Bruxelles - Brussel

1202

Sofia

1220

Vienna

1233

Sofia

1309

Sofia

1527

Sofia

2010

Darlinghurst

2400

Mol

2800

Mechelen

3100

Sankt Pölten

3181

Prahran

4020

Linz

4101

Bruderholz

4410

Liestal

4500

Huy

5020

Salzburg

6000

Stara Zagora

6060

Gilly

6900

Lugano

7000

Hobart

8000

Bruges

Székesfehérvár

8036

Graz

8091

Zurich

8200

Aarhus N

8800

Roeselare

Viborg

9000

Ghent

Aalborg

10016

Taipei

10034

Prague

11217

Taipei

11527

Athens

12808

Prague

14215

Buffalo

14233

Nea Ionia

17475

Greifswald

19803

Wilmington

20017

Milan

20138

Milan

20149

Milan

20246

Hamburg

22020

Como

24127

Bergamo

25123

Brescia

27100

Pavia

28222

Majadahonda

29425

Charleston

30342

Atlanta

30625

Hanover

31201

Macon

32209

Jacksonville

33308

Fort Lauderdale

33604

Pessac

34102

Naples

37045

Verona

38138

Germantown

38700

La Tronche

39008

Santander

43210

Columbus

45014

Fairfield

46010

Valencia

46026

Valencia

48149

Münster

48202

Detroit

50924

Cologne

52040

Arezzo

53215

Milwaukee

55422

Minneapolis

59037

Lille

60126

Ancona

60596

Frankfurt am Main

61348

Bad Homburg

66424

Homburg

69677

Bron

75908

Paris

76031

Rouen

80331

München

92708

Fountain Valley

99089

Erfurt

119228

Singapore

169609

Singapore

308433

Singapore

768828

Singapore

1528001

Tiberias

1834111

Afula

3810101

Hadera

4941492

Petah Tikva

6423906

Tel Aviv

7030000

Zrifin

7610001

Rehovot

7830604

Ashkelon

9103102

Jerusalem

70112-1396

New Orleans

39216-4505

Jackson

37232-8802

Nashville

M5B 1W8

Toronto

H1T 1C8

Montreal

H2W 1T8

Montreal

J3A 1C3

Saint-Jean-sur-Richelieu

J1G 2E8

Sherbrooke

G1V 4G5

Québec

500 05

Hradec Králové

767 01

Kroměříž

708 52

Fakultni nemocnice Ostrava, Ostrava

140 21

Prague

169 02

Prague

274 01

Slaný

DK-2900

Hellerup

H-2143

Kistarcsa

820-8505

Iizuka

670-0981

Himeji

920-8650

Kanazawa

252-5188

Sagamihara

236-0051

Yokohama

238-8567

Yokosuka

981-3133

Sendai

902-8511

Naha

569-1096

Takatsuki

581-0011

Yao

843-0393

Ureshino

773-8502

Komatsushimachō

152-8902

Meguro-ku

106-0031

Minato-ku

910-8526

Fukui

734-8530

Hiroshima

862-8505

Kumamoto

850-8555

Nagasaki

770-8539

Tokushima

930-8550

Toyama

1105 AZ

Amsterdam

7416 SE

Deventer

8441 PW

Heerenveen

8901 BR

Leeuwarden

5504 DB

Veldhoven

15-276

Bialystok

31-202

Krakow

59-220

Legnica

92-213

Lodz

10-010

Olsztyn

61-848

Poznan

02-507

Warsaw

138-736

Seoul

08907

L'Hospitalet de Llobregat

08003

Barcelona

08023

Barcelona

251 87

Helsingborg

651 85

Karlstad

581 85

Linköping

205 02

Malmo

701 85

Örebro

118 83

Stockholm

S44 5DX

Chesterfield

SG1 4AB

Stevenage

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY