276
Participants
Start Date
September 27, 2013
Primary Completion Date
August 31, 2018
Study Completion Date
July 10, 2019
Prevenar 13
Vaccination at the beginning of the study (day 0)
Pneumo23 / Pneumovax
Vaccination 2 months later the beginning of the study NB : Vaccine Pneumo23 has been replaced by equivalent vaccine Pneumovax in September 2017 because of the stop of commercialization of Pneumo23 in France by the pharmaceutical company
Methotrexate - Immediate
concerning immediate group, methotrexate is Initiated in the same time that the antipneumococcal vaccination by prevenar 13
Methotrexate - Delay
"For period group, methotrexate is Initiated \& month after the antipneumococcal vaccination by prevenar 13"
CHU La Conception, Marseille
CHU La Cavale Blanche, Brest
CHU Carémeau, Nîmes
CHU Purpan, Toulouse
CHU Pellegrin, Bordeaux
CHU de Montpellier - Hôpital Lapeyronie, Montpellier
CHU de Rennes, Rennes
CHU Trousseau, Tours
CHU Saint Etienne - Hôpital Nord, Saint-Etienne
CHU Orléans - Hôpital La Source, Orléans
CHU Montpied, Clermont-Ferrand
CHU Hautepierre, Strasbourg
CH Du Mans, Le Mans
CHU Saint Antoine, Paris
CHU La Pitié Salpétrière, Paris
CHU Bois Guillaume, Rouen
CHU Nord, Amiens
CHU Dupuytren, Limoges
CHU Bicetre, Le Kremlin-Bicêtre
CHPG Monaco - Hôpital Prince Grace de Monaco, Monaco
CHU de Nice - Hôpital L'Archet 1, Nice
Collaborators (1)
Hôpital Cochin
OTHER
Pfizer
INDUSTRY
University Hospital, Montpellier
OTHER