Colorectal Cancer Treated With Adjuvant Regorafenib Versus Placebo After Curative Treatment of Liver Metastases in a Randomized, Double-blind, Placebo-Controlled Phase-III STudy

PHASE3TerminatedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

December 2, 2013

Primary Completion Date

August 29, 2016

Study Completion Date

August 29, 2016

Conditions
Colorectal Neoplasms
Interventions
DRUG

Regorafenib (Stivarga, BAY73-4506)

Four tablets of 40mg taken orally daily in the morning, dose of 160 mg for 21 days of treatment followed by 7 days without treatment

DRUG

Placebo

Four tablets taken in the morning orally daily for 21 days of treatment followed by 7 days without treatment

Trial Locations (121)

2170

Liverpool

2650

Edegem

3000

Leuven

3002

East Melbourne

3144

Malvern

3165

Bentleigh East

4000

Liège

10021

New York

12200

Berlin

13210

Syracuse

13385

Marseille

14004

Córdoba

19104

Philadelphia

20089

Milan

20133

Milan

20141

Milan

25124

Brescia

26133

Oldenburg

27710

Duke University Medical Center, Durham

28007

Madrid

28034

Madrid

28040

Madrid

29285

Brest

33076

Bordeaux

33100

Udine

37044

Tours

37421

Chattanooga

38138

Germantown

42123

Reggio Emilia

46009

Valencia

46013

Valencia

48202

Detroit

50134

Florence

52482

Ramat Gan

55131

Mainz

55905

Rochester

56126

Pisa

60590

Frankfurt am Main

63000

Clermont-Ferrand

64239

Tel Aviv

68106

Omaha

69373

Lyon

70121

New Orleans

71013

Foggia

75390

Dallas

75651

Paris

80131

Napoli

81377

München

86021

Poitiers

90033

Los Angeles

90089

Los Angeles

90095

Los Angeles

92653

Laguna Hills

94800

Villejuif

98034

Kirkland

98101

Seattle

98109

Seattle

100021

Beijing

100071

Beijing

100142

Beijing

100730

Beijing

200030

Shanghai

200032

Shanghai

200127

Shanghai

310009

Hangzhou

310016

Hangzhou

350001

Fujian Medical University Union Hospital, Fuzhou

410008

Changsha

430033

Wuhan

510060

Guangzhou

510655

Guangzhou

650118

Kunming

710032

Xi'an

710038

Xi'an

3109601

Haifa

06520-8064

New Haven

21201-1595

Baltimore

08903-2681

New Brunswick

14263-0001

Buffalo

23298-0037

Richmond

30110-090

Belo Horizonte

Unknown

Porto Alegre

São José do Rio Preto

Harbin

01246-000

São Paulo

T6G 1Z2

Edmonton

M5G 1X8

Toronto

J1H 5N4

Sherbrooke

H2W 1S6

Montreal

00189

Rome

277-8577

Kashiwa

006-8555

Sapporo

060-0004

Sapporo

060-8648

Sapporo

673-8558

Akashi

660-8511

Amagasaki

650-0047

Kobe

309-1793

Kasama

241-8515

Yokohama

565-0871

Suita

569-8686

Takatsuki

411-8777

Sunto

329-0498

Shimotsuke

135-8550

Koto-ku

105-8471

Minato-ku

181-8611

Mitaka

142-8666

Shinagawa

160-8582

Shinjuku-ku

810-8563

Fukuoka

811-1395

Fukuoka

812-8582

Fukuoka

2801-951

Almada

4200-072

Porto

4520-531

Santa Maria da Feira

03010

Alicante

06080

Badajoz

08036

Barcelona

SM2 5PT

Royal Marsden NHS Trust (Surrey), Sutton

BS2 8ED

Bristol

SW3 6JJ

London

WC1E 6BT

London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY