150
Participants
Start Date
August 31, 2013
Primary Completion Date
September 30, 2014
Study Completion Date
September 30, 2014
Gravitational sympathetic stimulus
"Autonomic nervous system (ANS) activity is assessed by means of HRV, SAP variability and baroreflex control analysis daily from day 1 to discharge from ICU or day 28.~Analysis is performed (i)at rest in supine position with bed at zero degrees of inclination (ii) during modified tilt (MTILT) and (iii) recovery from MTILT in supine position at zero degrees. In a subgroup of patients motor sympathetic nervous activity (MSNA) is recorded at day 1,2 and 7.~MTILT consists in elevating head and trunk of patients at 60 degrees and lowering legs at 15 degree with a standard critical care bed. MSNA is recorded from the external peroneal nerve with microneurographic technique."
Istituto Clinico Humanitas, Rozzano
"Azienda Ospedaliera Luigi Sacco - Polo Universitario - University of Milan", Milan
Regione Lombardia
OTHER
ASST Fatebenefratelli Sacco
OTHER