Transplanted-like Heart in Critical Ill Patients

NACompletedINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

August 31, 2013

Primary Completion Date

September 30, 2014

Study Completion Date

September 30, 2014

Conditions
Autonomic Nervous System Dysfunction in Critically Ill
Interventions
OTHER

Gravitational sympathetic stimulus

"Autonomic nervous system (ANS) activity is assessed by means of HRV, SAP variability and baroreflex control analysis daily from day 1 to discharge from ICU or day 28.~Analysis is performed (i)at rest in supine position with bed at zero degrees of inclination (ii) during modified tilt (MTILT) and (iii) recovery from MTILT in supine position at zero degrees. In a subgroup of patients motor sympathetic nervous activity (MSNA) is recorded at day 1,2 and 7.~MTILT consists in elevating head and trunk of patients at 60 degrees and lowering legs at 15 degree with a standard critical care bed. MSNA is recorded from the external peroneal nerve with microneurographic technique."

Trial Locations (2)

20089

Istituto Clinico Humanitas, Rozzano

20157

"Azienda Ospedaliera Luigi Sacco - Polo Universitario - University of Milan", Milan

All Listed Sponsors
collaborator

Regione Lombardia

OTHER

lead

ASST Fatebenefratelli Sacco

OTHER

NCT01930669 - Transplanted-like Heart in Critical Ill Patients | Biotech Hunter | Biotech Hunter