19
Participants
Start Date
November 15, 2013
Primary Completion Date
April 6, 2016
Study Completion Date
April 6, 2016
PF-05212384
30 minute IV infusion of PF-05212384 on days 2, 9, 16 and 23 of each cycle. Intra-patient dose escalation will commence with 110mg and will increase depending on tolerability.
irinotecan
90 minutes IV infusion of irinotecan 180mg/m\^2 on days 1 and 15 of each cycle
Cetuximab
120 minute IV infusion of cetuximab 400mg/m\^2 on cycle 1 day 1; 60 minute IV infusion of cetuximab on days 8, 15, and 22 of each cycle, and on day 1 of each cycle after cycle 1
Irinotecan
90 minutes IV infusion of Irinotecan 180mg/m\^2 on days 1 and 15 of each cycle
Roswell Park Cancer Institute, Buffalo
Hospital General Universitario Gregorio Marañón, Madrid
Barnes-Jewish Hospital, St Louis
Washington University School of Medicine, St Louis
Siteman Cancer Center - South County, St Louis
Siteman Cancer Center - West County, Creve Coeur
Siteman Cancer Center - St Peters, City of Saint Peters
Regulatory Office: Comprehensive Cancer Centers of Nevada, Henderson
Comprehensive Cancer Centers of Nevada, Henderson
Comprehensive Cancer Centers of Nevada, Henderson
Comprehensive Cancer Centers of Nevada, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
Regulatory Management Only: TRIO-US Central Administration, Los Angeles
TRIO-US Central Administration (Regulatory Management only), Los Angeles
TRIO_US, Los Angeles
West Valley Hematology/Oncology Med Group, Northridge
CBCC Global Research, Inc. at Comprehensive Blood and Cancer Center, Bakersfield
Medical Oncology Associates, PS, Spokane
Spokane Valley Cancer Center, Spokane Valley
Kadlec Clinic Hematology and Oncology, Kennewick
Kadlec Medical Center, Richland
Outpatient Imaging Center, Richland
Drug Management Only: UCLA West Medical Pharmacy, Att: Steven L Wong, Pharm D, Los Angeles
Drug Management Only: UCLA West Medical Pharmacy, Los Angeles
UCLA West Medical Pharmacy, Los Angeles
Aichi cancer center central hospital, Nagoya
National Cancer Center Hospital East, Kashiwa
National Cancer Center, Goyang-si
Seoul National University Hospital / Department of Internal Medicine, Seoul
Samsung Medical Center, Seoul
Asan Medical Center, Seoul
Lead Sponsor
Pfizer
INDUSTRY