20
Participants
Start Date
August 31, 2013
Primary Completion Date
June 30, 2016
Study Completion Date
June 30, 2016
low intensity radiation therapy
50.4 Gy in 28 1.8 Gy fractions (IMRT or 3D-CRT), 5 days/week, starting 3-5 weeks after the last dose of induction chemotherapy
Capecitabine
825 mg/m2 PO twice daily, 5 days/week, beginning on the first day of radiation therapy and ending on the last day of radiation therapy.
Gemcitabine
1000 mg/m2 weekly as a 30 minute infusion after nab-Paclitaxel, three weeks on and 1 week off \[1 cycle = 4 weeks\]
high intensity radiation therapy
63 Gy intensity-modulated radiation therapy (IMRT) in 28 2.25 Gy fractions, 5 days/week, starts 3-5 weeks after the last dose of induction chemotherapy
nab-Paclitaxel
125 mg/m2 weekly as a 30-40 minute infusion, three weeks on and 1 week \[1 cycle = 4 weeks\]
University of Rochester, Rochester
Bryn Mawr Hospital, Bryn Mawr
Lankenau Medical Center, Wynnewood
University of Pennsylvania/Abramson Cancer Center, Philadelphia
Paoli Memorial Hospital, Paoli
Reading Hospital, West Reading
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Emory University/Winship Cancer Institute, Atlanta
Thompson Cancer Survival Center, Knoxville
Akron General Medical Center, Akron
Radiation Oncology Associates PC, Fort Wayne
Parkview Hospital Randallia, Fort Wayne
McFarland Clinic PC-William R Bliss Cancer Center, Ames
Iowa Methodist Medical Center, Des Moines
Bay Area Medical Center, Marinette
Saint Vincent Hospital, Green Bay
Saint Mary's Hospital, Green Bay
Mayo Clinic, Rochester
Rice Memorial Hospital, Willmar
Sanford Clinic North-Bemidgi, Bemidji
Roger Maris Cancer Center, Fargo
Sanford Bismarck Medical Center, Bismarck
Saint Joseph Hospital, Chicago
OSF Saint Francis Medical Center, Peoria
Decatur Memorial Hospital, Decatur
Mercy Hospital Saint Louis, St Louis
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Ochsner Medical Center Jefferson, New Orleans
M D Anderson Cancer Center, Houston
Huntsman Cancer Institute/University of Utah, Salt Lake City
Intermountain Medical Center, Murray
McKay-Dee Hospital Center, Ogden
Kaiser Permanente Cancer Treatment Center, South San Francisco
Kaiser Permanente Oakland-Broadway, Oakland
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC, Peoria
Boston Medical Center, Boston
Saint Joseph Mercy Hospital, Ann Arbor
Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County, Mount Holly
Capital Health Medical Center-Hopewell, Pennington
Rhode Island Hospital, Providence
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
University of Vermont Medical Center, Burlington
Door County Cancer Center, Sturgeon Bay
Collaborators (1)
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK