A Study Of PF-05212384 In Combination With Other Anti-Tumor Agents and in Combination With Cisplatin in Patients With Triple Negative Breast Cancer in an Expansion Arm (TNBC)

PHASE1CompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

September 10, 2013

Primary Completion Date

January 8, 2020

Study Completion Date

January 8, 2020

Conditions
Neoplasm
Interventions
DRUG

PF-05212384 (gedatolisib)

PF-05212384 weekly intravenous infusions starting at 90 mg/wk as a 3 week cycle

DRUG

Docetaxel

Docetaxel intravenous infusions once every 3 weeks starting at 75 mg/m\^2

DRUG

Cisplatin

Cisplatin intravenous infusions once every 3 weeks starting at 75 mg/m\^2

DRUG

Dacomitinib

Dacomitinib to be taken orally as a continuous once daily regimen at a starting dose of 30 mg

Trial Locations (29)

19111

Fox Chase Cancer Center, Philadelphia

20141

Istituto Europeo di Oncologia - Divisione Sviluppo di Nuovi Farmaci per Terapie Innovative, Milan

28041

Hospital Universitario 12 de Octubre, Madrid

29406

MUSC Specialty Care-North, North Charleston

29425

Medical University of South Carolina/ University Hospital, Charleston

Medical University of South Carolina, Charleston

MUSC SCTR Research, Charleston

29464

MUSC Health East Cooper, Mt. Pleasant

35233

University of Alabama at Birmingham, Birmingham

35249

University of Alabama at Birmingham, Birmingham

48201

Harper Professional Building, Detroit

Karmanos Cancer Institute, Detroit

80045

University of Colorado Denver CTO (CTRC), Aurora

University of Colorado Hospital, Aurora

90095

Ronald Reagan UCLA Medical Center, Los Angeles

UCLA Hematology Oncology, Los Angeles

Westwood Bowyer Clinic, Los Angeles

90404

Santa Monica UCLA Medical Center & Orthopaedic Hospital, Santa Monica

UCLA Hematology Oncology, Santa Monica

94115

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

02115

Brigham and Women's Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

V5Z 4E6

British Columbia Cancer Agency - Vancouver Centre, Vancouver

M5G 2M9

Princess Margaret Cancer Center, Toronto

00144

Istituto Regina Elena Struttura Complessa Oncologia Medica A, Roma

08035

Hospital Universitari Vall d'Hebron, Barcelona

W1T 7HA

University College London Hospital, NIHR UCLH Clinical Research Facility, London

OX3 7LE

Oxford Cancer Centre, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT01920061 - A Study Of PF-05212384 In Combination With Other Anti-Tumor Agents and in Combination With Cisplatin in Patients With Triple Negative Breast Cancer in an Expansion Arm (TNBC) | Biotech Hunter | Biotech Hunter