87,500
Participants
Start Date
September 30, 2013
Primary Completion Date
May 31, 2018
Study Completion Date
June 30, 2018
Community Engagement
The primary objective of the community engagement activities in CLIP will be to create awareness and action around the prevention of maternal morbidity and mortality due to pre-eclampsia/eclampsia. Community engagement involves the collective action of individuals, families, religious leaders, policy makers,
PIERS on the Move mHealth decision aid
This mHealth application is to be used by community health workers in intervention clusters to guide collection of relevant clinical data during antenatal visits. This clinical data is used to generate a risk estimate for any women with hypertension based on the miniPIERS (Pre-eclampsia Integrated Estimate of Risk) clinical risk prediction model. This risk estimate in combination with other pre-defined treatment triggers (severe hypertension (\>160mmHg systolic) or proteinuria (\>3+ dipstick); absence of fetal movements for greater than 12 hours; signs of recent stroke of seizure) are collected in the app and based on this data recommendations for care of the woman are provided.
Magnesium Sulfate
Women identified in intervention clusters by the community health worker during a study visit as being at high risk of- or having recently experienced- an eclamptic seizure will be given 10 g intramuscular magnesium sulfate prior to transfer to a nearby facility for further care.
Methyldopa
Women identified in intervention clusters as having severe hypertension (systolic greater than 160 mmHg) by the community health worker during a study visit will be given 750 mg of oral methyldopa prior to transfer to a nearby facility for further care.
Jawaharlal Nehru Medical College, Karnataka Lingayat Education University, Belagavi
Centro de Investigacaoem Saude de Manhica (CISM), Maputo
Centre for Research in Reproductive Health, Olabisi Onabanjo University, Sagamu
Aga Khan University, Karachi
Bill and Melinda Gates Foundation
OTHER
Olabisi Onabanjo University
OTHER
Centro de Investigacao em Saude de Manhica
OTHER
Aga Khan University
OTHER
Jawaharlal Nehru Medical College
OTHER
University of British Columbia
OTHER