A Study To Evaluate The Efficacy And Safety of The Investigational Drug PF-03446962 (A Monoclonal Antibody With Antiangiogenic Features) In Combination With Best Supportive Care Versus Placebo Plus Best Supportive Care In Patients Affected By Recurrent Liver Cancer

PHASE2TerminatedINTERVENTIONAL
Enrollment

3

Participants

Timeline

Start Date

October 31, 2013

Primary Completion Date

July 31, 2014

Study Completion Date

July 31, 2014

Conditions
Carcinoma, Hepatocellular
Interventions
DRUG

PF-03446962

PF 03446962 7 mg/kg, IV, every 2 weeks, until disease progression, patient refusal or unacceptable toxicity, whichever occurs first

OTHER

Best Supportive Care

BSC may include medications and supportive measures deemed necessary to palliate disease related symptoms and improve quality of life

OTHER

Placebo

Placebo will consist of Saline (0.9% w/v Sodium Chloride Injection, USP or NS)

OTHER

Best Supportive Care

BSC may include medications and supportive measures deemed necessary to palliate disease related symptoms and improve quality of life.

Trial Locations (4)

19111

Fox Chase Cancer Center, Philadelphia

277-8577

National Cancer Center Hospital East, Kashiwa

589-8511

Kinki University Hospital, Department of Gastroenterology and Hepatology, Ōsaka-sayama

104-0045

National Cancer Center Hospital, Chuo-ku

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY