100
Participants
Start Date
August 31, 2013
Primary Completion Date
February 28, 2014
Study Completion Date
April 30, 2014
induction of ovulation using letrozole-pioglitazone-metformin
induction of ovulation will be done for arm 1 for 3 consecutive cycles unless pregnancy occured.
induction of ovulation using clomiphene citrate-pioglitazone-metformin
induction of ovulation for arm 2 will be done in 3 consecutive cycles unless pregnancy occured.
transvaginal ultrasound
transvaginal ultrasound will be done starting from day 10 and every 48 hours until finding a follicle of \> 18 mm or till day 20 of the cycle
body mass index (BMI) calculation
BMI will be calculated for all women by dividing the weight in kilograms by the height in meters squared
day 3: follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), total testosterone
baseline hormonal assay (day 3 FSH, LH, TSH and total testosterone) will be done for all women.
pretreatment blood urea and serum creatinine
blood urea and serum creatinine will be assayed before stating induction of ovulation to have baseline levels.
serum estradiol (E2) on day 12
serum E2 will be assayed on day 12 of the cycle for all women.
serum progesterone on day 21
serum progesterone will be assayed on day 21 for all women to monitor ovulation.
blood urea and serum creatinine every month
blood urea and serum creatinine will be assayed every month during the treatment period to find out any hazards on kidney functions
Cairo University, Cairo
Cairo University
OTHER