A Two-part Study to Assess the Safety and Preliminary Efficacy of Givinostat in Patients With Polycythemia Vera

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

October 31, 2013

Primary Completion Date

June 26, 2017

Study Completion Date

September 25, 2017

Conditions
Polycythemia Vera
Interventions
DRUG

Givinostat

"In Part A patients will treated in dose levels at the following daily doses of Givinostat:~* 50 mg b.i.d.,~* 100 mg b.i.d.;~* 150 mg b.i.d.,~* 200 mg b.i.d.;~* 150 mg t.i.d.;~* 200 mg t.i.d.. Intermediate dose levels and, consequently, additionally dose levels may be used to establish the Maximum Tolerated Dose.~In Part B patients will be treated at the Maximum Tolerated Dose established in Part A. The product will be supplied as hard gelatine capsules for oral administration at the strength of 50 mg, 75 mg and/or 100 mg each."

Trial Locations (25)

10117

Charite Research Organisation GmbH, Berlin

24127

Azienda Ospedaliera Papa Giovanni XXIII, Bergamo

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

29609

Hôpital Morvan - CHRU de Brest, Brest

36100

Ospedale San Bortolo di Vicenza, Vicenza

50134

Azienda Ospedaliero-Universitaria Careggi, Florence, Florence

50937

Universitaetsklinikum Koeln, Cologne

56126

Azienda Ospedaliero Universitaria Pisana, Pisa

59020

Hopital Saint Vincent de Paul - GHICL Lille, Lille

70124

Azienda ospedaliero universitaria Consorziale Policlinico di Bari, Bari

Istituto Tumori Giovanni Paolo II - IRCCS Ospedale Oncologico di Bari, Bari

75475

Hôpital Saint-Louis (AP-HP), Centre Investigations Cliniques, Paris

79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

80054

CHU Amiens - Hôpital Sud, Amiens

80131

Università degli Studi di Napoli Federico II, Facoltà di Medicina e Chirurgia, Napoli

89125

"Azienda Ospedaliera Bianchi-Melacrino-Morelli", Reggio Calabria

01307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

Unknown

Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan

Ospedale Civile dello Spirito Santo, Pescara

Università Campus Bio-Medico di Roma, Rome

41-500

SP ZOZ Zespol Szpitali Miejskich w Chorzowie, Chorzów

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

BT9 7BL

Belfast City Hospital, Belfast

E1 1BB

Royal London Hospital, London

TR1 3LJ

Royal Cornwall Hospital, Truro

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Italfarmaco

INDUSTRY

NCT01901432 - A Two-part Study to Assess the Safety and Preliminary Efficacy of Givinostat in Patients With Polycythemia Vera | Biotech Hunter | Biotech Hunter