NCT01899560View on ClinicalTrials.gov

ELASTANCE: Prospective Physiological Study of Lung Elastance in Recruitment and Derecruitment in Early Onset Mechanically Ventilated ARDS Patients

PHASE3CompletedINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

March 31, 2013

Primary Completion Date

June 30, 2013

Study Completion Date

November 27, 2014

Conditions
Acute Respiratory Distress Syndrome
Interventions
PROCEDURE

Measure lung and chest wall elastance with esophageal catheter

"Patients will be in supine position with 30-45° head of bed elevation. The cuff of the endotracheal tube will be transiently overinflated to 60 cmH2O to ensure there will be no air leaks. NMBA (cisatracurium) will be administrated \[9\]. The fraction of inspired oxygen (FiO2) will be adjusted for continuously monitored oxygen saturation (SpO2) between 90 to 94%. Patients will be ventilated in pressure control with 15 cmH2O of driving pressure.~A low flow pressure/volume curve from 0 to 40 cmH2O will be performed."

OTHER

non-invasive method for measuring the lung elastance

by measuring volume recruited during a change of pressure (∆PEEP/∆EELV)

Trial Locations (1)

83056

Centre Hospitalier Intercommunal de Toulon La Seyne sur mer, Toulon

All Listed Sponsors
lead

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

OTHER

NCT01899560 - ELASTANCE: Prospective Physiological Study of Lung Elastance in Recruitment and Derecruitment in Early Onset Mechanically Ventilated ARDS Patients | Biotech Hunter | Biotech Hunter