Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

440

Participants

Timeline

Start Date

August 26, 2013

Primary Completion Date

December 31, 2031

Study Completion Date

December 31, 2031

Conditions
Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7Stage IVB Oropharyngeal Squamous Cell Carcinoma AJCC v7
Interventions
RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMPT

OTHER

Laboratory Biomarker Analysis

Correlative studies

RADIATION

Photon Beam Radiation Therapy

Undergo IMRT

RADIATION

Proton Beam Radiation Therapy

Undergo IMPT

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (22)

10035

New York Proton Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

22031

Inova Schar Cancer Institute, Fairfax

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

32610

University of Florida Health Science Center - Gainesville, Gainesville

33176

Miami Cancer Institute, Miami

35249

University of Alabama at Birmingham, Birmingham

48201

Wayne State University/Karmanos Cancer Institute, Detroit

55905

Mayo Clinic in Rochester, Rochester

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

71103

Willis-Knighton Medical and Cancer Center, Shreveport

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

77079

MD Anderson West Houston, Houston

77384

MD Anderson in The Woodlands, Conroe

77478

MD Anderson in Sugar Land, Sugar Land

77573

MD Anderson League City, League City

85259

Mayo Clinic in Arizona, Scottsdale

98109

Fred Hutch/University of Washington Cancer Consortium, Seattle

02114

Massachusetts General Hospital Cancer Center, Boston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

National Institute of Dental and Craniofacial Research (NIDCR)

NIH

lead

M.D. Anderson Cancer Center

OTHER

NCT01893307 - Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer | Biotech Hunter | Biotech Hunter