295
Participants
Start Date
June 7, 2013
Primary Completion Date
April 23, 2019
Study Completion Date
June 5, 2019
Sultamicillin
"Standard of care: Each patient will receive inhaled fast-acting bronchodilators (up to a maximum of 4 - 6 times daily 2 puffs (100µg) of salbutamol or other equivalent inhaled fast-acting bronchodilators), systemic corticosteroids (prednisolone 40mg/d p.o. for 7 - 10 days) and oxygen in case of hypoxemia in a standardized fashion. The pre-existing COPD medication will be continued as indicated.~Experimental intervention:~Antibiotic therapy with aminopenicillin + betalactamase inhibitor (oral Sultamicillin (2 x 750mg)) for 5 days as supplement to standard of care for patients with AE-COPD."
Placebo
"Standard of care: Each patient will receive inhaled fast-acting bronchodilators (up to a maximum of 4 - 6 times daily 2 puffs (100µg) of salbutamol or other equivalent inhaled fast-acting bronchodilators), systemic corticosteroids (prednisolone 40mg/d p.o. for 7 - 10 days) and oxygen in case of hypoxemia in a standardized fashion. The pre-existing COPD medication will be continued as indicated.~Control intervention:~Placebo for 5 days as supplement to standard of care for patients with AE-COPD"
Universitätsklinikum Aachen, Aachen
Krankenhaus Bad Arolsen, Bad Arolsen
Lungenklinik Ballenstedt, Ballenstedt
Charité - Universitätsmedizin Berlin, Berlin
HELIOS Klinikum Emil von Behring Berlin, Berlin
Pneumologische Praxis am Schloss Charlottenburg Berlin, Berlin
Vivantes Klinikum Neukölln, Berlin
Vivantes Klinikum Spandau, Berlin
Klinikum der Ruhr-Universität Bochum, Bochum
Pneumologische Gemeinschaftspraxis Bonn, Bonn
Forschungszentrum Borstel, Borstel
Klinikum Dortmund gGmbH, Dortmund
Universitätsklinikum Dresden, Dresden
Pneumologische Klinik Waldhof Elgershausen, Elgershausen
Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen
Praxis Dr. med. Ina Itzigehl Euskirchen, Euskirchen
Universitätsklinikum Freiburg, Freiburg im Breisgau
Universitätsmedizin Greifswald, Greifswald
HELIOS Klinik Hagen-Ambrock, Hagen
Elbpneumologie Hamburg, Hamburg
Schwerpunktpraxis Colonnaden Hamburg, Hamburg
Medizinische Hochschule Hannover, Hanover
Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg
Universitätsklinikum Heidelberg, Heidelberg
Lungenfachklinik Immenhausen, Immenhausen
Universitätsklinikum Jena, Jena
Universitätsklinikum Schleswig-Holstein Kiel, Kiel
Universitätsklinikum Schleswig-Holstein Campus Lübeck, Lübeck
Brüderkrankenhaus St. Josef Paderborn, Paderborn
Diakoniekrankenhaus Rotenburg, Rotenburg (Wümme)
Krankenhaus Bethanien Solingen, Solingen
HELIOS Klinikum Wuppertal-Barmen, Wuppertal
CAPNETZ Stiftung
OTHER
Hannover Medical School
OTHER