104
Participants
Start Date
January 31, 2014
Primary Completion Date
June 30, 2017
Study Completion Date
June 30, 2017
Exercise
All participants will take part in 3 days/week of structured aerobic, stretching, and balance training for weeks 1-12. For weeks, 13-24, training will be reduced to 2 days/week and a resistance training component added. Participants will also be expected to engage in 2 bouts of 30 minutes of home-based walking per week.
ACE inhibitor + exercise
In addition to exercise training, participants will receive an initial perindopril dose of 2 mg/day which will be titrated to 4 mg/day.
Thiazide diuretic + exercise
In addition to exercise training, participants will receive an initial hydrochlorothiazide dose of 12.5 mg/day which will be titrated to 25 mg/day.
Angiotensin receptor blocker + exercise
In addition to exercise training, participants will receive an initial losartan dose of 50 mg/day which will be titrated to 100 mg/day.
UF Institute on Aging Clinical and Translational Research Building, Gainesville
American Heart Association
OTHER
University of Florida
OTHER