Effect of Chronic Incretin-based Therapy in Cystic Fibrosis

NACompletedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

June 30, 2013

Primary Completion Date

December 31, 2019

Study Completion Date

March 31, 2020

Conditions
Cystic FibrosisPancreatic Insufficiency
Interventions
DRUG

Sitagliptin

The GPA test as described in the primary outcome section will be performed at baseline and after 6 months of therapy in the Sitagliptin and placebo arms. Furthermore, evaluation of endogenous GLP-1 levels will be assessed by a mixed meal tolerance test compared at baseline and 6 months.

DRUG

Placebo

The GPA test as described in the primary outcome section will be performed at baseline and after 6 months of therapy in the Sitagliptin and placebo arms. Furthermore, evaluation of endogenous GLP-1 levels will be assessed by a mixed meal tolerance test compared at baseline and 6 months.

Trial Locations (1)

19194

Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia

All Listed Sponsors
collaborator

Children's Hospital of Philadelphia

OTHER

lead

University of Pennsylvania

OTHER

NCT01879228 - Effect of Chronic Incretin-based Therapy in Cystic Fibrosis | Biotech Hunter | Biotech Hunter