Evaluation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TA-8995 With Single, Escalating Doses in Healthy Subjects

TA-8905 5, 10, 25, 50 (fasted and fed), 100 and 150 mg

Drug: TA-8995 25 mg

Drug: TA-8995 25 mg

Drug: TA-8995 25, 50, 100 and 150 mg

Single ascending dose in Caucasian men

Age-effect in Caucasian men

Gender-effect in Caucasian women

Single ascending dose in Japanese men