PAZOPANIB Efficacy and Tolerance in Desmoids Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

September 18, 2012

Primary Completion Date

March 31, 2018

Study Completion Date

September 30, 2019

Conditions
Progressive Desmoids Tumors
Interventions
DRUG

PAZOPANIB treatment

"Pazopanib~* 800 mg per day~* oral administration~* at least 1 hour before or 2 hours after a meal,~* until disease progression or for 12 months maximum"

DRUG

Active Comparator: Vinblastine and Methotrexate

Active Comparator: Vinblastine and Methotrexate vinblastine 5 mg / m², methotrexate 30 mg / m (J1, J8, J15, J21, 6 months and then J1, J15) 28 days per cycle until disease progression or for 12 months.

Trial Locations (1)

33000

Institut Bergonié, Bordeaux

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Institut Bergonié

OTHER