Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement

PHASE4CompletedINTERVENTIONAL
Enrollment

194

Participants

Timeline

Start Date

January 31, 2014

Primary Completion Date

December 31, 2015

Study Completion Date

December 31, 2015

Conditions
Osteoarthritis
Interventions
DRUG

Tranexamic Acid (TXA)

1g in 250cc of saline given over 30 minutes just prior to raising the tourniquet and making the initial incision. A second 1g in 250cc of saline will be infused over 30 minutes beginning at the time of wound closure.

DRUG

ε-Aminocaproic Acid (EACA)

7g in 250cc of saline given over 30 minutes just prior to raising the tourniquet and making the initial incision. A second 7g of EACA in 250cc saline will be infused over 30 minutes beginning at the time of wound closure.

Trial Locations (1)

51503

Miller Orthopedic Specialists, Council Bluffs

All Listed Sponsors
collaborator

CHI Health Mercy Hospital

OTHER

collaborator

Creighton University Medical Center

OTHER

lead

Miller Orthopedic Specialists

OTHER

NCT01873768 - Clinical Efficacy of Tranexamic Acid and ε-Aminocaproic Acid in Reducing Blood Loss Following Total Knee Replacement | Biotech Hunter | Biotech Hunter