Study to Evaluate GSK3052230 in Combination With Paclitaxel and Carboplatin, or Docetaxel or as Single Agent in Subjects With Solid Malignancies and Deregulated Fibroblast Growth Factor (FGF) Pathway Signaling

PHASE1CompletedINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

October 9, 2013

Primary Completion Date

October 24, 2017

Study Completion Date

October 24, 2017

Conditions
Neoplasms
Interventions
DRUG

GSK3052230

A clear to opalescent, colorless to pale yellow solution for IV infusion once weekly (Day 1, Day 8, Day 15) in each 21-day cycle with unit dose strengths/dose level of 5, 10, 15, and 20 mg/kg supplied in a sterile 25 mL glass vial.

DRUG

paclitaxel

paclitaxel will be from commercial stock.

DRUG

carboplatin

carboplatin will be from commercial stock.

DRUG

docetaxel

docetaxel will be from commercial stock.

DRUG

pemetrexed

pemetrexed will be from commercial stock

DRUG

cisplatin

cisplatin will be from commercial stock

Trial Locations (29)

2100

GSK Investigational Site, Koebenhavn Oe

3000

GSK Investigational Site, Leuven

10065

GSK Investigational Site, New York

28034

GSK Investigational Site, Madrid

28040

GSK Investigational Site, Madrid

29010

GSK Investigational Site, Málaga

29425

GSK Investigational Site, Charleston

41013

GSK Investigational Site, Seville

43210

GSK Investigational Site, Columbus

48201

GSK Investigational Site, Detroit

60637

GSK Investigational Site, Chicago

63110

GSK Investigational Site, St Louis

91010

GSK Investigational Site, Duarte

95817

GSK Investigational Site, Sacramento

163045

GSK Investigational Site, Arkhangelsk

188663

GSK Investigational Site, Vsevolozhsk

197758

GSK Investigational Site, Saint Petersburg

198255

GSK Investigational Site, Saint Petersburg

390011

GSK Investigational Site, Ryazan

61615-7822

GSK Investigational Site, Peoria

27599-7600

GSK Investigational Site, Chapel Hill

1066 CX

GSK Investigational Site, Amsterdam

197 089

GSK Investigational Site, Saint Petersburg

06080

GSK Investigational Site, Badajoz

08028

GSK Investigational Site, Barcelona

08035

GSK Investigational Site, Barcelona

LE1 5WW

GSK Investigational Site, Leicester

SE1 9RT

GSK Investigational Site, London

NG5 1PB

GSK Investigational Site, Nottingham

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY