NCT01867047 - ACE-Inhibitor Effects on Total Hip and Knee Arthroplasty Patients | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 30, 2013

Primary Completion Date

June 24, 2016

Study Completion Date

June 24, 2016

Conditions

Adverse Effects of Angiotensin-converting-enzyme InhibitorsHypotension

Interventions

DRUG

ACE-I Cessation group

"Subjects stop ACE-I 48 hours prior to surgery. Examples of possible ACE-I drugs include:~benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), trandolapril (Mavik)"

DRUG

ACE-I Continuation group

"Subjects take ACE-I through day of surgery. Examples of possible ACE-I drugs include:~benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec, Epaned), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), trandolapril (Mavik)"

Trial Locations (1)

27710

Duke University, Durham