10
Participants
Start Date
June 30, 2013
Primary Completion Date
July 31, 2014
Study Completion Date
July 31, 2014
methyl donor
The design will include a 2 week placebo run-in followed by a baseline blank study (2-hrs exposure to medical air) to provide benchmarks for all assessed variables. Participants will then receive a 4-week placebo treatment before the first PM2.5 exposure study. A 4-week methyl-donor treatment (Dose: 2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12 once a day) will precede the 2nd PM2.5 exposure.
Placebo
Placebo
Gage Occupational and Environmental Health St. Michael's Hospital/University of Toronto, Toronto
University of Toronto
OTHER
Unity Health Toronto
OTHER
Harvard School of Public Health (HSPH)
OTHER