Dose Escalation, Multi-arm Study of MLN4924 Plus Docetaxel, Gemcitabine, or Combination of Carboplatin and Paclitaxel in Participants With Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

June 10, 2013

Primary Completion Date

May 21, 2018

Study Completion Date

May 21, 2018

Conditions
Solid Tumors
Interventions
DRUG

MLN4924

"MLN4924 (intravenously \[IV\]) in participants in a 21-day cycle:~* MLN4924 on Days 1,3,5 of each cycle"

DRUG

Paclitaxel

"Paclitaxel (IV) in a 21-day cycle:~* Paclitaxel on Day 1 of each cycle"

DRUG

Gemcitabine

"Gemcitabine (IV) in participants in a 28-day cycle:~-Gemcitabine on Days 1,8,15 of each cycle"

DRUG

Docetaxel

"Docetaxel (IV) in participants in a 21-day cycle:~\- Docetaxel on Day 1 of each cycle"

DRUG

Carboplatin

"Carboplatin (IV) in participants in a 21-day cycle:~\- Carboplatin on Day 1 of each cycle"

Trial Locations (6)

19104

Philadelphia

27599

Chapel Hill

30322

Atlanta

37203

Nashville

63110

St Louis

44106-4948

Cleveland

All Listed Sponsors
lead

Millennium Pharmaceuticals, Inc.

INDUSTRY