718
Participants
Start Date
November 7, 2013
Primary Completion Date
October 14, 2016
Study Completion Date
October 14, 2016
Tocilizumab (TCZ)
TCZ will be administered at a dose of 162 milligrams (mg) via SC injection weekly (if body weight is greater than or equal to \[\>/=\] 100 kilograms \[kg\]) or every 2 weeks (if body weight was less than \[\<\] 100 kg).
Methotrexate (MTX)
MTX will be administered at a stable dose (15 mg to 25 mg per week) orally.
Placebo (PBO)
PBO matching to MTX will be administered orally.
Manhattan Medical Reserach, New York
Manhasset Rheumatology, Manhasset
Arthritis & Osteoporosis Center, Brooklyn
Rheumatology Associates of Long Island, Smithtown
Office of Premier Chatpar Md, Plainview
The Center for Rheumatology, Albany
Arthritis Health Associates, Syracuse
Buffalo Rheumatology Associates, Orchard Park
Advanced Rheumatology & Arthritis Research Center, Wexford
Arthritis Associates, Erie
Altoona Center For Clinical Research, Duncansville
Arthritis Group, Philadelphia
Clinical Research Center of Reading, Wyomissing
Emkey Arthritis & Osteoporosis, Wyomissing
Javed Rheumatology Associates, Inc., Newark
Rheumatolgy Consultants of Deleware, Lewes
Klein & Associates, M.D., P.A., Hagerstown
Mountain State Clinical Research, Clarksburg
Medication Management, Greensboro
Shanahan Rheumatology & Immunology, PLLC, Raleigh
Triangle Orthopaedics Associates, P.A., Durham
Carolina Bone & Joint P.A., Charlotte
Cape Fear Arthritis Care, Leland
PMG Research of Hickory LLC, Hickory
Asheville Arthritis & Osteoporosis Center, PA, Asheville
Columbia Arthritis Center (Partnership Practice), Columbia
Low Country Rheumatology, PA, Charleston
Piedmont Arthritis Clinic, Greenville
North Georgia Rheumatology Group, PC, Lawrenceville
North Georgia Rheumatology, Duluth
Arthritis Center of North Georgia, Gainesville
Rheumatology Associates of Central Florida, Orlando
Arthritis and Rheumatology Clinic, Orlando
Precision Research Organization, Miami Lakes
Suncoast Research Group LLC, Miami
South Coast Research Center, Inc., Miami
Arthritis & Rheumatism; Disease Specialities, Aventura
West Broward Rheumatology Associates, Inc., Tamarac
McIlwain Medical Group, Tampa
Burnette & Silverfield, MDS, Tampa
Pinellas Medical Research - Allegry & Rheumatology Associates, LLC, St. Petersburg
Jeffrey Alper M.D Research, Naples
Sarasota Arthritis Res Center, Sarasota
Arthritis Center Palm Harbor, Palm Harbor
Arthritis Rsrch of Florida, Inc., Palm Harbor
Robert Levin, Md; Research Dept, Dunedin
Advanced Clinical Research of Orlando, Inc., Winter Garden
Uni Of Alabama,Birmingham; Medicine - Rheumatology, Birmingham
Clnical & Translational Reseach Center for Alabama, PC, Tuscaloosa
Rheumatology Associates of North Alabama, Huntsville
Pinnacle Research Group; Llc, Central, Anniston
Ramesh Gupta - PP, Memphis
West Tennessee Research Institute, Jackson
Arthritis and Osteoporosis; Treatment and Research Center, Flowood
Jackson Arthritis Clinic, Flowood
Bluegrass Comm Research, Inc., Lexington
Ohio State University; Rheumatology; Immun/Rheum, Columbus
Columbus Arthritis Center, Columbus
Clinical Research Source, Inc., Toledo
University Hospitals Case Medical Center, Cleveland
Paramount Medical Research, Middleburg Heights
Crystal Arthritis Center, Inc., Akron
Cincinnati Rheumatic Disease Study Group, Cincinnati
STAT Research Inc, Dayton
Indiana Uni Medical Center, Indianapolis
Diagnostic Rheumatology & Research, Indianapolis
Shores Rheumatology, Saint Clair Shores
Advanced Rheumatology, PC, Lansing
Fiechtner Research Inc, Lansing
Nisus Research/Northern Michigan Hospital, Petoskey
Rheumatic Disease Center, Glendale
Lakeshore Orthopedics, Manitowoc
Gundersen Clinic Ltd;Sec. Rheumatology/Dept. of Internal Med, Onalaska
St. Paul Rheumatology, Eagan
St. Luke's Hospital Association of Duluth, Duluth
St. Alexius Medical Center; Arthritis Clinic, Bismarck
Odyssey Research Services; Main Medical Building, Bismarck
Springfield Clinic, Springfield
David S Rosenberg, Florissant
Clayton Medical Research, St Louis
Arthritis Consultants, St Louis
Clinical Research Consultants,LLC, Kansas City
Kansas City Internal Medicine, Overland Park
Arthritis & Diabetes Clinic, Inc, Monroe
CHI St. Vincent Medical Group Hot Springs, Hot Springs
Little Rock Diagnostic Clinic, Little Rock
NEA Baptist Clinic, Jonesboro
Fort Smith Rheumatology, PC, Fort Smith
Arthritis and Rheumatology; Center of Oklahoma PLLC, Oklahoma City
Health Research of Oklahoma, Llc, Oklahoma City
Lynn Health Science Inst., Oklahoma City
Arthritis Care Center Oklahoma, Ardmore
Oklahoma Center For Arthritis Therapy & Research, Tulsa
Healthcare Research Consultants, Tulsa
Southwest Rheumatology, Mesquite
Metroplex Clinical Research, Dallas
Arthritis & Osteoporosis Clinic, Waco
Rheumatic Disease Clin Res Ctr, Houston
IntraFusion Researh Network, Houston
Houston Inst. For Clinical Research, Houston
Accurate Clinical Research, Houston
Diagnostic Group, Beaumont
AOCBV, College Station
Crossroads Clinical Research, LLC, Victoria
Accurate Clinical Management, San Antonio
NextGen Clinical Research Inc, San Antonio
Arthiritis & Osteoporosis Centre of South Texas, San Antonio
Adriana Pop-Moody MD Clinic PA, Corpus Christi
Arthritis Clinic Of Central Texas, San Marcos
Austin Regional Clinic, Austin
Lovelace Scientific Resources Inc., Austin
Amarillo Center For Clinical Research, Amarillo
University of Colorado Hospital, Aurora
Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs, Colorado Springs
Institute of Arthritis Research, Idaho Falls
Valley Arthritis Care, Phoenix
Arizona Arthritis & Rheumatology Research, Pllc, Mesa
Arizona Arthritis and Rheuma, Mesa
Advanced Arthritis Care & Research, Scottsdale
Arizona Arthritis & Rheumatology Associates, P.C., Glendale
Albuquerque Clinical Trials, Albuquerque
Arthritis and Osteoporosis Associates of New Mexico, Las Cruces
G. T. Kelly, MD, Las Vegas
Medvin Clinical Research, Whittier
Valerius Medical Group, Los Alamitos
Medvin Clinical Research, Covina
TriWest Research Associates, LLC, El Cajon
San Diego Arthritis Med Clnc, San Diego
CV Mehta MD Medical Corp, Hemet
St. Jude Hospital Yorba Linda DBA St. Joseph, Fullerton
NRC Research Institute, Orange
C Michael Neuwelt MD Inc, San Leandro
South Puget Sound Clinical Research, Olympia
Wenatchee Valley Hospital & Clinics, Wenatchee
Arthritis Northwest, Spokane, Spokane
Inland Rheumatology; Clinical Trials, Inc., Upland
Denver Arthritis Clinic, Denver
Joao Nascimento, Bridgeport
Clinical Research Center of Ct/Ny, Danbury
Arthritis & Osteoporosis Center Pc, Hamden
New England Research Associates, Trumbull
New England Medical Center; Dept. of Medicine, Div. of Rheumatology, Boston
Phase Iii Clinical Research, Fall River
Mansfield Medical Center, Mansfield
Reliant Medical Group, Inc; Rheumatology, Worcester
UMass Memorial Medical Center, Worcester
Clinical Pharmacology Study Group, Worcester
Rheumatology Research Group, Lebanon
Nashua Rheumatology - Foundation Medical Partners, Nashua
Arthritis and Osteoporosis Associates, Manalapan
Atlantic Coast Rheumatology, Toms River
Ocean Rheumatology, Toms River
Arthritis Rheumatic & Back Disease Associates, Voorhees Township
Cooper Cancer Institute, Voorhees Township
Arthritis Care & Diagnostic Center, Dallas
Hoffmann-La Roche
INDUSTRY