Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN)

PHASE1RecruitingINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

February 28, 2014

Primary Completion Date

December 31, 2025

Study Completion Date

February 29, 2036

Conditions
Non-Hodgkin LymphomaChronic Lymphocytic LeukemiaAcute Lymphocytic Leukemia
Interventions
GENETIC

Dose Escalation Phase:CD19.CAR/28 and CD19.CAR/28137 T cells

"Three dose levels will be evaluated.~Group 1: CD19.CAR/28137ζ at 1×10\^6 cells/m\^2 and CD19.CAR/28ζ at 1×10\^6 cells/m\^2~Group 2: CD19.CAR/28137ζ at 5×10\^6 cells/m\^2 and CD19.CAR/28ζ at 5×10\^6 cells/m\^2~Group 3: CD19.CAR/28137ζ at 2×10\^7 cells/m\^2 and CD19.CAR/28ζ at 2×10\^7 cells/m\^2"

GENETIC

Expansion Phase: CD19.CAR/28 and CD19.CAR/28137 T cells

The primary goal of the expanded cohort is to further study the safety profiles of CAR-T cells in each of the disease settings, both with or without lymphodepleting chemotherapy given before CAR-T cell infusion.

Trial Locations (2)

77030

RECRUITING

Houston Methodist Hospital, Houston

RECRUITING

Texas Children's Hospital, Houston

All Listed Sponsors
collaborator

Center for Cell and Gene Therapy, Baylor College of Medicine

OTHER

collaborator

The Methodist Hospital Research Institute

OTHER

lead

Baylor College of Medicine

OTHER