3,470
Participants
Start Date
December 26, 2012
Primary Completion Date
January 2, 2018
Study Completion Date
January 2, 2018
LS tumor screening
All participants with CRC or EC will have LS tumor screening (MSI, IHC, methylation if applicable).
Genetic testing
"Next-generation sequencing panel of several genes that increase the risk for hereditary cancers including the LS genes (MLH1, MSH2, MSH6, PMS2, EPCAM), polyposis genes (MUTYH, APC), and others.~The following study participants will have free genetic testing:~* CRC and EC study participants with unmethylated MSI-high (MSI-H) tumors~* CRC and EC study participants with microsatellite stable (MSS) or MSI-low (MSI-L) tumors who have abnormal IHC results and they do not have methylation of the MLH1 promoter~* CRC study participants diagnosed with CRC \<50 years, regardless of tumor studies or family history~* CRC study participants diagnosed with CRC ≥ 50 years with a FDR with CRC or EC OR synchronous or metachronous CRC or EC throughout their life, regardless of tumor studies.~At-risk relatives of the individuals found to have LS are eligible for free single site genetic testing."
Genetic Counseling
"The participants found to have LS or another type of hereditary cancer will have free genetic counseling.~At-risk relatives of the individuals found to have LS are eligible for free genetic counseling."
Biorepository
The biorepository is an optional part of the OCCPI. CRC and EC participants will contribute leftover tumor and blood samples, as well as a saliva sample. FDR of the CRC participants will contribute a saliva sample. The at-risk relatives of those found to have LS will contribute blood and saliva samples.
Questionnaire
Grady Memorial Hospital, Delaware
Knox Community Hospital, Mount Vernon
Licking Memorial Hospital, Newark
Mount Carmel St. Ann's Hospital, Westerville
Fairfield Medical Center, Lancaster
Mount Carmel East Hospital, Columbus
Riverside Methodist Hospital, Columbus
Grant Medical Center, Columbus
Mount Carmel West Hospital, Columbus
Doctors Hospital, Columbus
St. Luke's Hospital (ProMedica), Maumee
Flower Hospital (ProMedica Health System), Sylvania
Toledo Hospital (Promedica Health System), Toledo
Genesis Cancer Care Center (Genesis Healthcare System), Zanesville
Akron General Medical Center, Akron
MetroHealth, Cleveland
Fairview Hospital, Cleveland
Hillcrest Hospital, Mayfield Heights
Cleveland Clinic, Cleveland
Summa Barberton (Summa Health System), Barberton
Summa Western Reserve (Summa Health System), Cuyahoga Falls
Robinson Memorial (Summa Health System), Ravenna
Akron City/St. Thomas Hospital (Summa Health System), Akron
Mercy Medical Center, Canton
Aultman Hospital, Canton
Atrium Medical Center, Middletown
The Christ Hospital, Cincinnati
Good Samaritan Hospital (TriHealth), Cincinnati
Bethesda North Hospital (TriHealth), Cincinnati
Wayne Healthcare, Greenville
Upper Valley Medical Center, Troy
Miami Valley Hospital, Dayton
Good Samaritan Hospital Dayton, Dayton
Kettering Medical Center, Dayton
Wright-Patterson Medical Center, Dayton
Springfield Regional Medical Center, Springfield
Adena Health System, Chillicothe
Southern Ohio Medical Center, Portsmouth
Marietta Memorial Hospital, Marietta
St. Rita's Medical Center, Lima
Blanchard Valley Health System, Findlay
Mercy Clermont, Batavia
Mercy Anderson, Cincinnati
Mercy West, Cincinnati
The Jewish Hospital, Cincinnati
Mercy Fairfield, Fairfield
Marion General Hospital, Marion
Toledo Clinic Cancer Center, Maumee
South Pointe Hospital, Warrensville Heights
Ohio State University Comprehensive Cancer Center
OTHER