26
Participants
Start Date
May 31, 2013
Primary Completion Date
November 30, 2023
Study Completion Date
December 31, 2024
Thymoglobulin
"Day 9 before BMT: 0.5mg/kg IV; Days 8 \& 7 before BMT: 2mg/kg IV~Days 8 \& 7 - 2mg/kg IV before BMT"
Fludarabine
Days 6 and 2 before BMT: 30mg/m2/day IV
Cyclophosphamide (CTX)
Days 6 and 5 before BMT: 14.5mg/kg IV; Days 3 and 4 after BMT: 50mg/kg/day
Mesna
Days 3 \& 4 after BMT: 40 mg/kg IV
Sirolimus
Adjusted to maintain a serum trough level of 3-12 ng/mL, taken orally beginning on 5 days after BMT and taken to 1 year after BMT.
Mycophenolate mofetil (MMF)
15 mg/kg orally with maximum dose 3 mg/day beginning 5 days after BMT and taken to day 35 after BMT
Bone marrow transplantation
Day 0 - Transplantation of hematopoietic cells derived from bone marrow of a donor to a recipient as treatment for hematologic disorders
Total body irradiation
200 cGy on the day before BMT. Radiation delivered to the entire body of the recipient to eradicate bone marrow cells in the recipient to prepare the recipient to receive the transplanted
Vanderbilt-Ingram Cancer Center, Nashville
Saint-Louis Hospital, Paris
St Mary's Hospital, London
Vanderbilt-Ingram Cancer Center
OTHER