ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial

PHASE3CompletedINTERVENTIONAL
Enrollment

823

Participants

Timeline

Start Date

June 30, 2013

Primary Completion Date

November 30, 2022

Study Completion Date

November 30, 2022

Conditions
End Stage Renal Failure on Dialysis
Interventions
DRUG

Spironolactone

After a month in run-in period under 25 mg per 2 days of spironolactone administered per os in practice after dialysis session three times a week, patients will be randomized to spironolactone. The dose should be increased to 25 mg once daily and could be adjusted in using an algorithm used in the EPHESUS and EMPHASIS-HF trials.

DRUG

Placebo

After a month in run-in period under 25 mg per 2 days of spironolactone administered per os in practice after dialysis session three times a week, patients will be randomized to placebo. The dose should be increased to 25 mg once daily and could be adjusted in using an algorithm used in the EPHESUS and EMPHASIS-HF trials.

Trial Locations (70)

1070

Hôpital Erasme- Bruxelles, Brussels

10003

CH Troyes, Troyes

13006

Clinique Bouchard, Marseille

13009

Adpc Marseille, Marseille

13385

APHM Marseille, Marseille

14033

CHU Caen, Caen

21079

CHU Dijon Hôpital du Bocage, Dijon

22000

CHG St Brieuc, Saint-Brieuc

25000

CHU Besançon, Besançon

29260

Centre de Perharidy, Roscoff

29609

CHRU Brest, Brest

31059

CHU Toulouse, Toulouse

35000

CHU Rennes, Rennes

35400

Aub Saint Malo, St-Malo

35403

Ch Saint Malo, St-Malo

37000

CHU Tours, Tours

38043

AGDUC Grenoble, Grenoble

44093

CHU Nantes, Nantes

44402

ECHO Confluent, Rezé

46000

CH Cahors, Cahors

50100

CHPC Cherbourg, Cherbourg

51100

CHU de Reims, Reims

51726

ARPDD Reims, Reims

54500

CHU Nancy, Nancy

54504

ALTIR Nancy, Vandœuvre-lès-Nancy

55107

CH Verdun, Verdun

57000

Association de Metz, Metz

57070

Hôpitaux Privés de Metz- Hôpital Robert Schuman, Vantoux

58085

ALTIR Metz, Metz

CHR Metz-Thionville, Metz

59000

Clinique Lille, Lille

59037

CHU Lille, Lille

59056

CH Roubaix, Roubaix

59322

CH Valenciennes, Valenciennes

62321

CH Boulogne Sur Mer, Boulogne-sur-Mer

67000

AURAL St Anne (AURAL Strasbourg), Strasbourg

CHU Strasbourg, Strasbourg

Clinique Sainte Anne, Strasbourg

67200

AURAL Strasbourg, Strasbourg

67500

AURAL Haguenau, Haguenau

CH Haguenau, Haguenau

68000

AURAL Colmar, Colmar

68024

Hopitaux Civils de Colmar, Colmar

68100

AURAL Mulhouse, Mulhouse

CH Mulhouse, Mulhouse

69003

CHU de Lyon, Lyon

69004

AURAL La Croix Rousse, Lyon

69007

CH St Joseph-St Luc, Lyon

69008

AURAL Lyon, Lyon

69495

CHU Lyon Sud, Pierre-Bénite

73000

CH Chambéry, Chambéry

75013

AP-HP La Salpêtrière, Paris

75014

AURA Paris 14ème, Paris

AURA Paris Plaisance, Paris

75020

Hôpital Tenon, Paris

75743

AP-HP Necker, Paris

77400

Polyclinique de Lagny, Lagny

80054

CHU Amiens, Amiens

84000

CH Avignon, Avignon

85000

La Roche Sur Yon, La Roche-sur-Yon

87000

ALURAD Limoges, Limoges

87042

CHU Limoges, Limoges

94010

APHP Henri Mondor, Créteil

97405

CHU de la Réunion Hôpital Félix Guyon, Saint-Denis

07100

CH Ardeche Nord, Annonay

06002

CHU Nice, Nice

06100

Clinique St Georges, Nice

Unknown

Institut Mutualiste Montsouris, Paris

CH Princesse Grace, Monaco

03201

CH Vichy, Vichy

All Listed Sponsors
collaborator

Central Hospital, Nancy, France

OTHER

collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

lead

University Hospital, Brest

OTHER

NCT01848639 - ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial | Biotech Hunter | Biotech Hunter