Immunotherapy Study in Borderline Resectable or Locally Advanced Unresectable Pancreatic Cancer

PHASE3TerminatedINTERVENTIONAL
Enrollment

302

Participants

Timeline

Start Date

May 31, 2013

Primary Completion Date

July 29, 2016

Study Completion Date

March 24, 2017

Conditions
Pancreatic CancerPancreatic Carcinoma Non-resectableLocally Advanced Malignant Neoplasm
Interventions
DRUG

FOLFIRINOX

FOLFIRINOX consisting of Oxaliplatin 85 mg/m\^2 IV over 2 hours; Irinotecan 180 mg/m\^2 IV over 90 minutes; Leucovorin 400 mg/m\^2 IV over 2 hours; Fluorouracil 2.4 g/m\^2 IV over 46 hours

BIOLOGICAL

Algenpantucel-L Immunotherapy

Algenpantucel-L Immunotherapy (HAPa) consisting of 300 Million HAPa cells given by intradermal injection

RADIATION

5-FU Chemoradiation

5-FU Chemoradiation consisting of 5-FU continuous IV infusion of 200-250 mg/m\^2/day given 5-7 days each week over 5.5 weeks concurrently with external beam radiation

DRUG

Gemcitabine

Gemcitabine 1000 mg/m\^2 given intravenously over 30 minutes for 3 weeks (days 1, 8 and 15) with 1 week rest.

DRUG

Capecitabine

Capecitabine consisting of 825 mg/m\^2 PO BID M-F concurrently with external beam radiation

DRUG

Nab-Paclitaxel

Nab-Paclitaxel 125 mg/m\^2 given intravenously over 30-40 minutes

Trial Locations (32)

10029

Mount Sinai Medical Center, New York

19107

Thomas Jefferson University, Philadelphia

22904

University of Virginia, Charlottesville

27157

Wake Forest Baptist Health, Winston-Salem

32610

University of Florida, Gainesville

33136

University of Miami, Miami

33486

Boca Raton Regional Hospital, Boca Raton

33606

USF Tampa General, Tampa

33612

H. Lee Moffitt Cancer Center, Tampa

37920

University of Tennessee Medical Center, Knoxville

40292

University of Louisville, Louisville

43210

The Ohio State University, Columbus

46202

Indiana University, Indianapolis

46526

Indiana University Health Goshen Center for Cancer Care, Goshen

48073

Beaumont CCOP, Royal Oak

53792

University of Wisconsin, Madison

54311

Vince Lombardi Cancer Center, Green Bay

60005

Illinois Cancer Specialists, Arlington Heights

66205

University of Kansas Cancer Center, Westwood

73104

University of Oklahoma, Oklahoma City

75390

University of Texas Southwestern Medical Center, Dallas

77030

Baylor College of Medicine, Houston

85719

Arizona Cancer Center, Tucson

89502

Renown Regional Medical Center, Reno

90048

Cedars-Sinai Medical Center, Los Angeles

94115

California Pacific Medical Center, San Francisco

95816

Sutter Institute for Medical Research, Sacramento

97239

Oregon Health and Science University, Portland

98109

University of Washington - Seattle Cancer Center Alliance, Seattle

06902

Stamford Hospital, Stamford

55407-3799

Virginia Piper Cancer Institute, Minneapolis

07753

Jersey Shore University Medical Center, Neptune City

Sponsors
All Listed Sponsors
lead

NewLink Genetics Corporation

INDUSTRY

NCT01836432 - Immunotherapy Study in Borderline Resectable or Locally Advanced Unresectable Pancreatic Cancer | Biotech Hunter | Biotech Hunter