Safety Study of ADV-specific T-cells in Paediatric Patients Post Allo-HSCT

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

8

Participants

Timeline

Start Date

December 31, 2012

Primary Completion Date

December 31, 2016

Study Completion Date

December 31, 2016

Conditions
ADV Infection Post Allo-HSCT
Interventions
BIOLOGICAL

Cytovir-ADV

"A single dose 1x10e4 CD3+ T cells/kg patient weight of Cytovir ADV is prescribed to patients on exhibiting two consecutive PCR positive Adenovirus viraemia results \> 1000 copies/ml. Patients are followed up by continued monitoring of Adenovirus viraemia results. If patients exhibit uncontrolled ADV viraemia at ≥ 4 weeks following the first cell dose, they will be prescribed a second cell dose of 10e5 CD3+ T cell/kg. Patients will be monitored for 6 months following infusion of Cytovir ADV.~This is a feasibility/pilot study and has no control group"

Trial Locations (3)

Unknown

Great Ormond Street Hospital, London

Royal Manchester Children's Hospital, Manchester

Royal Victoria Infirmary, Newcastle

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Technology Strategy Board, United Kingdom

OTHER

lead

Cell Medica Ltd

INDUSTRY

NCT01822093 - Safety Study of ADV-specific T-cells in Paediatric Patients Post Allo-HSCT | Biotech Hunter | Biotech Hunter